{"id":"W4213065278","doi":"10.1038/s41467-022-28551-x","title":"Disruption of the grid cell network in a mouse model of early Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation; Canada Research Chairs; Scottish Rite Charitable Foundation of Canada; Government of Canada","keywords":"Entorhinal cortex; Neuroscience; Hippocampal formation; Hippocampus; Grid cell; Genetically modified mouse; Biology; Alzheimer's disease; Disease; Transgene; Grid; Medicine; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003187547,0.001199011,0.0005581324,0.001730285,0.0005244439,0.0005906797,0.0006596238,0.001155656,0.002648826],"category_scores_gemma":[0.0002186891,0.000560645,0.0005531199,0.0005065731,0.0006904181,0.0006529136,0.0004484725,0.00190674,0.0009453132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006077318,"about_ca_system_score_gemma":0.0004328112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001899477,"about_ca_topic_score_gemma":0.003402784,"domain_scores_codex":[0.9996408,0.00004404671,0.00005392539,0.00009920164,0.00009185754,0.00007000333],"domain_scores_gemma":[0.9995301,0.00004918026,0.0001582722,0.00005602963,0.00005319019,0.0001533167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004560179,0.0003965943,0.0004603041,0.00006460561,0.00002745704,0.0004945644,0.00009211877,0.0001808923,0.9948549,0.0005115077,0.0002530541,0.002207865],"study_design_scores_gemma":[0.0004142043,0.002664706,0.01661496,0.00009378456,0.0001771039,0.00325388,0.0002712072,0.005731957,0.9600093,0.001241895,0.009474562,0.00005245977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850225,0.001502319,0.00800966,0.0004032712,0.0001869046,0.0001220384,0.001558236,0.0006956137,0.002499399],"genre_scores_gemma":[0.9713515,0.001902036,0.01044213,0.0002129617,0.00003449503,0.0003762823,0.001727216,0.0002050288,0.01374835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002648826,"threshold_uncertainty_score":0.008861244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04928279368998469,"score_gpt":0.3407194354819422,"score_spread":0.2914366417919575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}