{"id":"W4213071463","doi":"10.1093/jcag/gwab049.141","title":"A142 IMPACT OF <i>HLADQA1*05G&amp;gt;A</i> GENETIC-SCREENING FOR OPTIMAL ANTI-TNF THERAPY IN INFLAMMATORY BOWEL DISEASE: A PRELIMINARY REPORT","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Discontinuation; Medicine; Azathioprine; Inflammatory bowel disease; Adverse effect; Population; Thiopurine methyltransferase; Internal medicine; Prospective cohort study; Tumor necrosis factor alpha; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001424997,0.0002813294,0.0005033896,0.0001299854,0.0001683159,0.0004718358,0.0002608636,0.0004832499,0.003229504],"category_scores_gemma":[0.002226087,0.00009135712,0.0007545577,0.0001757705,0.0002684734,0.0001933964,0.0001649102,0.000415784,0.0003510031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002163317,"about_ca_system_score_gemma":0.0005284658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009635354,"about_ca_topic_score_gemma":0.0009793834,"domain_scores_codex":[0.9992393,0.0005144619,0.00005867388,0.0000711078,0.00006266953,0.0000537426],"domain_scores_gemma":[0.9979631,0.001030521,0.0003324558,0.00009295739,0.0001799147,0.0004011169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5338305,0.03584183,0.2002697,0.001525358,0.001924198,0.001352216,0.0003307412,0.0006048006,0.04664962,0.0002708203,0.001982593,0.1754175],"study_design_scores_gemma":[0.02938964,0.619372,0.3359502,0.0002211253,0.002569613,0.001031244,0.0002602227,0.00107585,0.005930651,0.0002006552,0.003964144,0.00003458203],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967078,0.001552065,0.0002437995,0.0002012495,0.00006417473,0.000214921,0.0001248274,0.000006045992,0.0008852212],"genre_scores_gemma":[0.9976883,0.000644601,0.0006502568,0.0001923479,0.0001113186,0.0001033041,0.0001734173,0.000002563955,0.0004339818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003229504,"threshold_uncertainty_score":0.01080376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008553124947819369,"score_gpt":0.2329609645009242,"score_spread":0.2244078395531048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}