{"id":"W4213072947","doi":"10.1038/s41594-022-00724-8","title":"Structural basis for DNA targeting by the Tn7 transposon","year":2022,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Transposable element; DNA; Biology; Mutant; Mutation; DNA-binding protein; Cell biology; Binding site; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002502009,0.0003408605,0.0002869103,0.00005769814,0.0007107443,0.00002608922,0.000592951,0.0004222826,0.00001969095],"category_scores_gemma":[0.0001529458,0.0002360034,0.0003699217,0.0002275323,0.0002138207,0.000004354207,0.0002001951,0.0006300096,2.434242e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004782421,"about_ca_system_score_gemma":0.00004555772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001496636,"about_ca_topic_score_gemma":0.000009698716,"domain_scores_codex":[0.9980167,0.0002686034,0.0003102192,0.0007152691,0.0001810511,0.0005082091],"domain_scores_gemma":[0.9991438,0.00003353561,0.0001854088,0.0004446116,0.0001243626,0.00006830481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001727308,0.000005169252,0.0001566922,0.000007012514,0.0001303149,0.000002677096,0.00002067864,0.00003847117,0.9909613,0.0008960565,0.003914019,0.003694838],"study_design_scores_gemma":[0.00041038,0.0005004975,0.0001309675,0.00000247656,0.00008235907,0.00007729378,0.0001159371,0.0002214444,0.9327739,0.002194693,0.06308246,0.0004075611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874619,0.004343719,0.003673126,0.002554129,0.000455861,0.000548357,0.0008185101,0.00007147154,0.00007291254],"genre_scores_gemma":[0.9899826,0.00002542901,0.004069336,0.002877421,0.0002407092,0.00007464216,0.002539984,0.00004278092,0.0001471067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05916844,"threshold_uncertainty_score":0.962394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003774601294636855,"score_gpt":0.2834691625497206,"score_spread":0.2796945612550837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}