{"id":"W4213072947","doi":"10.1038/s41594-022-00724-8","title":"Structural basis for DNA targeting by the Tn7 transposon","year":2022,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Transposable element; DNA; Biology; Mutant; Mutation; DNA-binding protein; Cell biology; Binding site; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722321,0.0003510219,0.0002638046,0.0002184969,0.0003863265,0.0005010794,0.0005914005,0.0009118062,0.002374093],"category_scores_gemma":[0.0004263117,0.0002299746,0.0004034512,0.0001063879,0.0004884274,0.000286602,0.0003363111,0.001017024,0.001248665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005090823,"about_ca_system_score_gemma":0.0005397713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007229242,"about_ca_topic_score_gemma":0.0005779163,"domain_scores_codex":[0.9998564,0.0000182958,0.000009356138,0.0000231784,0.00005840948,0.00003446209],"domain_scores_gemma":[0.9997396,0.00008039638,0.00003954949,0.00002972494,0.0000441198,0.00006659319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006929236,0.00003520073,0.0002200411,0.00004083321,0.000007871013,0.0003163232,0.00002508517,0.0006170225,0.9897564,0.007161563,0.0001124377,0.001637864],"study_design_scores_gemma":[0.00003464362,0.0003897538,0.002456576,0.00001569235,0.00002188001,0.0009356148,0.00008602473,0.009100109,0.9791803,0.003595342,0.00416196,0.00002218042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956892,0.0006563272,0.03189917,0.0009138474,0.0002284813,0.0000661684,0.0001987523,0.0003921898,0.008753125],"genre_scores_gemma":[0.9945221,0.0001603124,0.003624168,0.0001450936,0.00001860646,0.00001489378,0.0001985315,0.00002971846,0.001286549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002374093,"threshold_uncertainty_score":0.00794208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003774601294636855,"score_gpt":0.2834691625497206,"score_spread":0.2796945612550837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}