{"id":"W4213074975","doi":"10.1002/ctm2.722","title":"EEF2K silencing inhibits tumour progression through repressing SPP1 and synergises with BET inhibitors in melanoma","year":2022,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Melanoma; Cancer research; Gene silencing; Small interfering RNA; STAT3; Chromatin immunoprecipitation; Medicine; Biology; Transfection; Cell culture; Phosphorylation; Cell biology; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460984,0.0003926939,0.0003765668,0.0002484188,0.0001108825,0.000216114,0.0001460026,0.0002353532,0.0009883529],"category_scores_gemma":[0.00009490104,0.0001114899,0.000284945,0.0001332618,0.0001809356,0.0001621922,0.0001365778,0.0005455834,0.0002411318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002153771,"about_ca_system_score_gemma":0.0001734829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002192486,"about_ca_topic_score_gemma":0.0007782706,"domain_scores_codex":[0.9998953,0.00001582559,0.00001076932,0.00001664227,0.00003031822,0.00003119491],"domain_scores_gemma":[0.9999558,0.000007351314,0.00001045765,0.00000526168,0.000005463137,0.00001557954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005526246,0.0001650873,0.000404616,0.0001773605,0.00002652664,0.00007820352,0.00001698623,0.000252803,0.9918017,0.0001088274,0.0003047119,0.006110693],"study_design_scores_gemma":[0.0001891547,0.001748431,0.009407707,0.00002465522,0.00009075121,0.0006169549,0.00004942709,0.002797538,0.9757528,0.0001324871,0.009177566,0.00001254234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898572,0.005114654,0.001756944,0.0002103456,0.00009552738,0.00005696002,0.0004979289,0.0001867466,0.002223767],"genre_scores_gemma":[0.9952214,0.001663415,0.0008386316,0.00008328988,0.00001299633,0.00005599801,0.0004539427,0.00001861801,0.001651578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009883529,"threshold_uncertainty_score":0.003306389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666650762524162,"score_gpt":0.327150321323421,"score_spread":0.3004838136981793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}