{"id":"W4213074975","doi":"10.1002/ctm2.722","title":"EEF2K silencing inhibits tumour progression through repressing SPP1 and synergises with BET inhibitors in melanoma","year":2022,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Melanoma; Cancer research; Gene silencing; Small interfering RNA; STAT3; Chromatin immunoprecipitation; Medicine; Biology; Transfection; Cell culture; Phosphorylation; Cell biology; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004977082,0.0001231143,0.0001983105,0.00004479309,0.0001649958,0.000008815002,0.00005444067,0.00007123265,0.00003424487],"category_scores_gemma":[0.0001012877,0.00009016678,0.00002723474,0.0001216779,0.0003191638,0.00001408349,0.00005982341,0.0002174526,2.577994e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003362011,"about_ca_system_score_gemma":0.00005699363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002952594,"about_ca_topic_score_gemma":0.00002405978,"domain_scores_codex":[0.998677,0.0001358387,0.0004231598,0.0003931449,0.0002386723,0.0001321976],"domain_scores_gemma":[0.9996012,0.0000837623,0.0001009354,0.0001016194,0.00003260459,0.00007985776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001907686,0.0004990453,0.7559658,0.0001589823,0.0001019815,0.00007468306,0.00138823,0.0002414963,0.1398655,0.001886567,0.001952286,0.09595768],"study_design_scores_gemma":[0.03046501,0.01147073,0.6957474,0.002514245,0.0002333523,0.000586625,0.003370852,0.001843087,0.1570897,0.008351196,0.08651503,0.001812738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911199,0.004131968,0.0002600994,0.003477789,0.0001261641,0.0002304313,0.00000772894,0.00001092725,0.000635002],"genre_scores_gemma":[0.9979243,0.0002202163,0.00083045,0.0004485735,0.0003531773,0.00003448466,0.0001145958,0.00001197258,0.00006219706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09414494,"threshold_uncertainty_score":0.3676895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666650762524162,"score_gpt":0.327150321323421,"score_spread":0.3004838136981793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}