{"id":"W4213077533","doi":"10.21203/rs.3.rs-1370997/v1","title":"Sexual Dimorphism in Reactive Oxygen Species Production and a Role for Integrin alpha 1 beta 1 in Estrogen Receptor Expression in Articular Cartilage","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Cartilage; Sexual dimorphism; Chondrocyte; Nitrotyrosine; Reactive oxygen species; Estrogen receptor; Integrin; Estrogen; Ex vivo; Osteoarthritis; Cell biology; Internal medicine; Estrogen receptor beta; Endocrinology; Biology; Estrogen receptor alpha; Receptor; In vivo; Medicine; Pathology; Anatomy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003230214,0.0001615624,0.0002117178,0.0004580257,0.0001182969,0.0003150576,0.0001637619,0.0002203705,0.00298264],"category_scores_gemma":[0.0002900118,0.0001467217,0.0001822355,0.0001835167,0.0001846185,0.0001621602,0.000169414,0.0003032572,0.0003765544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542464,"about_ca_system_score_gemma":0.0001248435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002404619,"about_ca_topic_score_gemma":0.000366051,"domain_scores_codex":[0.9997706,0.00004545393,0.00002501214,0.00006054379,0.00006321302,0.00003526581],"domain_scores_gemma":[0.9997087,0.00004532887,0.0001220172,0.00003075027,0.0000378136,0.00005532764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005086166,0.00009382808,0.01384767,0.00007718609,0.00002401919,0.0002987956,0.00008473323,0.00004568008,0.976925,0.0004256816,0.0002155751,0.007453325],"study_design_scores_gemma":[0.00008262748,0.001390149,0.696242,0.00006004269,0.00009019281,0.004606414,0.0004023172,0.0006472341,0.2890192,0.0009181164,0.0065001,0.00004166373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906136,0.002852139,0.002227903,0.000191123,0.00003198018,0.00003420759,0.00137784,0.00003874055,0.002632516],"genre_scores_gemma":[0.9937801,0.0007916877,0.0006510286,0.0001183459,0.00001280917,0.0000595497,0.0005862883,0.00002111465,0.003979078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00298264,"threshold_uncertainty_score":0.009977937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04569600937820993,"score_gpt":0.3541618009314503,"score_spread":0.3084657915532404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}