{"id":"W4213138117","doi":"10.1038/s41467-022-28601-4","title":"Heterotypic interactions drive antibody synergy against a malaria vaccine candidate","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Malaria Research and Control","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Diamond Light Source; Wellcome Trust; Wellcome","keywords":"Epitope; Antibody; Monoclonal antibody; Plasmodium falciparum; Malaria vaccine; Virology; Biology; Immune system; Malaria; Immunity; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002930955,0.0002750926,0.000369953,0.0002159914,0.0002114295,0.0003604146,0.0002744523,0.0003716959,0.001802706],"category_scores_gemma":[0.0003675904,0.0002432294,0.0002076563,0.0001202629,0.0002401331,0.0003385609,0.0004657549,0.000639146,0.0004710327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002207208,"about_ca_system_score_gemma":0.0001670207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001811274,"about_ca_topic_score_gemma":0.0004760825,"domain_scores_codex":[0.9995524,0.0001002036,0.00001891536,0.00008261541,0.0001172505,0.0001284764],"domain_scores_gemma":[0.9997986,0.00005835255,0.00004631063,0.00002260612,0.00002459091,0.00004951863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000621103,0.00004316083,0.0005165555,0.0000292189,0.00001230565,0.00004010597,0.00001203554,0.0004706652,0.9959438,0.0002834064,0.00009966315,0.002486872],"study_design_scores_gemma":[0.00003308077,0.00100831,0.006670169,0.000008002379,0.00004034271,0.0005942379,0.00004635922,0.009079466,0.977886,0.0004820263,0.004142288,0.000009743329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986128,0.001201462,0.007383587,0.0001292059,0.00002086258,0.00005626347,0.00006584312,0.00008571231,0.004929217],"genre_scores_gemma":[0.9966589,0.0002110009,0.002324502,0.0001131649,0.000009057763,0.00002161676,0.0000484138,0.00001075396,0.0006025546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001802706,"threshold_uncertainty_score":0.006030679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288122479122449,"score_gpt":0.3362748089923396,"score_spread":0.3233935842011151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}