{"id":"W4213142988","doi":"10.1021/acschembio.1c00855","title":"Termination of Poly- <i>N</i> -acetylglucosamine (PNAG) Polymerization with <i>N</i> -Acetylglucosamine Analogues","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Sick Kids Foundation; Canadian Institutes of Health Research; Government of Ontario","keywords":"Biofilm; Glycosyltransferase; Virulence; N-Acetylglucosamine; Bacteria; In vitro; Polysaccharide; In vivo; Microbiology; Chemistry; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000202001,0.0001835853,0.0002392663,0.0001056136,0.0001125711,0.000008554835,0.0003245705,0.0001383578,0.0001440159],"category_scores_gemma":[0.00008557465,0.0001654251,0.00006788179,0.0003882391,0.0002437849,0.000006751432,0.0003361761,0.0001809035,0.000004506509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002823011,"about_ca_system_score_gemma":0.00009164135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004837242,"about_ca_topic_score_gemma":0.000009093717,"domain_scores_codex":[0.9985604,0.0001434403,0.0003109966,0.0004418462,0.0002240746,0.0003192158],"domain_scores_gemma":[0.9992058,0.00003028035,0.0001734562,0.0003803165,0.0001242437,0.00008591337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004390898,0.0001667165,0.002377738,0.00001582909,0.00004357733,0.000002186662,0.00002527083,0.00001305367,0.9853621,0.000354747,0.0003654307,0.01083432],"study_design_scores_gemma":[0.001148319,0.001001578,0.0003619655,0.000003800519,0.00001280956,0.00004708098,0.0000682053,0.00005290171,0.9628438,0.00004326203,0.0342194,0.0001968441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951823,0.001054633,0.001304081,0.0005749984,0.00006841972,0.0002949424,0.000166316,0.00002464302,0.001329646],"genre_scores_gemma":[0.9945507,0.00009308055,0.0006113302,0.0004162814,0.0001160675,0.0001187013,0.003686075,0.00002678858,0.0003809589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03385396,"threshold_uncertainty_score":0.6745841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007919135812893188,"score_gpt":0.2472579302788628,"score_spread":0.2393387944659696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}