{"id":"W4213142988","doi":"10.1021/acschembio.1c00855","title":"Termination of Poly- <i>N</i> -acetylglucosamine (PNAG) Polymerization with <i>N</i> -Acetylglucosamine Analogues","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Sick Kids Foundation; Canadian Institutes of Health Research; Government of Ontario","keywords":"Biofilm; Glycosyltransferase; Virulence; N-Acetylglucosamine; Bacteria; In vitro; Polysaccharide; In vivo; Microbiology; Chemistry; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001939067,0.0004418757,0.000217414,0.00008660628,0.0001032738,0.0002928921,0.0002159774,0.0002299814,0.000432059],"category_scores_gemma":[0.0002462693,0.0001150696,0.0002797777,0.0001253858,0.0002071565,0.0001848545,0.0001622607,0.0004935622,0.0002146637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003190241,"about_ca_system_score_gemma":0.0002145796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007024297,"about_ca_topic_score_gemma":0.0007066284,"domain_scores_codex":[0.9998226,0.00004412258,0.00001464816,0.00003398417,0.00004924131,0.00003551545],"domain_scores_gemma":[0.9998415,0.00002862392,0.00005670916,0.00002345895,0.00002131938,0.00002831792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000939205,0.00002019707,0.00009604109,0.0000238525,0.000003381981,0.000024645,0.000008488139,0.0001002147,0.9984686,0.0001238896,0.0000214759,0.001015305],"study_design_scores_gemma":[0.000002245967,0.00009499707,0.0002559254,0.000001542307,0.000001998235,0.00002996428,0.000002135949,0.0002192918,0.9988809,0.00001244246,0.0004971388,0.000001360547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843348,0.001441945,0.01040797,0.00008589728,0.00005353546,0.00006190596,0.0002990691,0.0001047757,0.003210151],"genre_scores_gemma":[0.9883008,0.0009315084,0.008347118,0.0000651409,0.000009325021,0.00003470076,0.0003446006,0.00003750536,0.001929329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007024297,"threshold_uncertainty_score":0.002314627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007919135812893188,"score_gpt":0.2472579302788628,"score_spread":0.2393387944659696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}