{"id":"W4213155579","doi":"10.1200/jco.2022.40.6_suppl.540","title":"Association of TMB and PD-L1 with efficacy of first-line pembrolizumab (pembro) or pembro + chemotherapy (chemo) versus chemo in patients (pts) with advanced urothelial carcinoma (UC) from KEYNOTE-361.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Internal medicine; Logistic regression; Oncology; Pembrolizumab; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001896775,0.0002110514,0.0005225049,0.0001752053,0.0001649555,0.0005064221,0.0003098394,0.0006116786,0.002207429],"category_scores_gemma":[0.003266976,0.0001750245,0.0008093073,0.0002821556,0.0002391429,0.0005855103,0.000321641,0.001169739,0.0002399036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004395554,"about_ca_system_score_gemma":0.000342367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003587748,"about_ca_topic_score_gemma":0.0006505756,"domain_scores_codex":[0.9993924,0.0002505408,0.00004533264,0.0001731716,0.0000615423,0.00007684559],"domain_scores_gemma":[0.9975165,0.001194842,0.0007987771,0.0001140901,0.00005426392,0.0003216557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3717217,0.001653934,0.5599809,0.0006592624,0.00268935,0.0001514014,0.0001732771,0.001715975,0.01067483,0.0001606204,0.001480795,0.0489379],"study_design_scores_gemma":[0.007376927,0.05030018,0.9318612,0.00006824321,0.002161949,0.0003876106,0.00009474768,0.003358868,0.002134262,0.0003237552,0.001898886,0.00003340633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976421,0.001134389,0.0001024371,0.0001070902,0.00001416513,0.00003123455,0.000613871,0.000008374426,0.0003463235],"genre_scores_gemma":[0.999183,0.00008671477,0.00008320744,0.0000536562,0.00001520091,0.00002614321,0.0003604341,0.000001728405,0.0001898703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002207429,"threshold_uncertainty_score":0.01003116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04539994209956121,"score_gpt":0.3712161611350521,"score_spread":0.3258162190354909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}