{"id":"W4213158558","doi":"10.1093/jcag/gwab049.237","title":"A238 ALTERED GUT MICROBIOME COMPOSITION AND FUNCTION ARE ASSOCIATED WITH GUT BARRIER DYSFUNCTION IN HEALTHY RELATIVES OF CROHN’S DISEASE PATIENTS","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Ottawa; McMaster University; University of Calgary; University of Alberta; Mount Sinai Hospital; McMaster University Medical Centre; Hospital for Sick Children; Public Health Ontario; BC Children's Hospital; University of Toronto","funders":"","keywords":"Cohort; Gut flora; Microbiome; Gut microbiome; Barrier function; Internal medicine; Biology; Feces; Medicine; Physiology; Immunology; Genetics; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003612328,0.0003999545,0.0004234873,0.0006359402,0.0005989787,0.000504679,0.000246498,0.0004126822,0.003920411],"category_scores_gemma":[0.001728248,0.0002273731,0.000443393,0.0006623075,0.0001895607,0.000281929,0.0003634149,0.000415768,0.0004247366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001908728,"about_ca_system_score_gemma":0.0001422101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002998735,"about_ca_topic_score_gemma":0.00246759,"domain_scores_codex":[0.9996712,0.00007875964,0.00003302764,0.0001204199,0.0000436177,0.0000529757],"domain_scores_gemma":[0.9993277,0.0001390929,0.0002726482,0.00006736942,0.00005942774,0.0001337203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007651884,0.00004796585,0.992754,0.00002570109,0.0001240742,0.0007376075,0.0001350797,0.00007262533,0.001858525,0.00004039071,0.0003792825,0.003059627],"study_design_scores_gemma":[0.00001509573,0.0001644234,0.996792,0.00001546236,0.00008091619,0.001621718,0.0001964921,0.0003398348,0.000220435,0.00008912928,0.0004580391,0.000006327072],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989908,0.0002506435,0.00011981,0.00004177109,0.00001100546,0.000002595904,0.0002886865,0.000007922094,0.000286777],"genre_scores_gemma":[0.9995319,0.00004494792,0.00008745633,0.00001632144,0.000009001964,0.000002835164,0.0001610588,0.000003060848,0.0001433039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003920411,"threshold_uncertainty_score":0.01311505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003844882118507463,"score_gpt":0.1857221242104334,"score_spread":0.1818772420919259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}