{"id":"W4213161885","doi":"10.2139/ssrn.4037715","title":"Complementary Gene Regulation by NRF1 and NRF2 Protect Against Hepatic Cholesterol Overload","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Regina; University of Saskatchewan","funders":"","keywords":"Cholesterol; Gene; NRF1; Biology; Cell biology; Chemistry; Computational biology; Internal medicine; Medicine; Genetics; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002101636,0.0002762672,0.0006286573,0.0002278383,0.0001870394,0.0002468497,0.0001829563,0.0003380796,0.00431966],"category_scores_gemma":[0.0001916991,0.0001381832,0.0003857603,0.0001438154,0.0002114869,0.0003475871,0.0002735769,0.0006192511,0.0007016052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001417066,"about_ca_system_score_gemma":0.0002037247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001962762,"about_ca_topic_score_gemma":0.0004988796,"domain_scores_codex":[0.999889,0.0000233573,0.00001187505,0.00002570543,0.00001726233,0.00003275229],"domain_scores_gemma":[0.9999186,0.000007129869,0.00002184032,0.00001506172,0.00001701148,0.00002038619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008686142,0.0004556483,0.001073241,0.0004379959,0.00012444,0.0001664587,0.00006010165,0.000120753,0.9682131,0.0008042621,0.0006310104,0.01922694],"study_design_scores_gemma":[0.001102591,0.005969536,0.02260915,0.00008575965,0.0004872312,0.0009223988,0.0003908307,0.001768279,0.9478653,0.001416463,0.0173415,0.00004099947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885378,0.004864214,0.002336443,0.0004617886,0.0001916147,0.00003611852,0.0005046013,0.000135064,0.00293241],"genre_scores_gemma":[0.9912116,0.00163055,0.001453044,0.0001676965,0.0000405206,0.00004660758,0.0005031569,0.00001988654,0.004926971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00431966,"threshold_uncertainty_score":0.01445073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006735922420408207,"score_gpt":0.2318957746902748,"score_spread":0.2251598522698665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}