{"id":"W4213162889","doi":"10.21203/rs.3.rs-30934/v3","title":"COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; U.S. Air Force; Defense Advanced Research Projects Agency; Defense Threat Reduction Agency; Advanced Research Projects Agency; U.S. Department of Defense","keywords":"Histamine; Famotidine; Mast cell; Coronavirus disease 2019 (COVID-19); Mechanism (biology); Pandemic; Immunology; Mechanism of action; Dysfunctional family; Histamine H2 receptor; Medicine; Receptor; Disease; Biology; Pharmacology; Internal medicine; Infectious disease (medical specialty); Antagonist; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","open_science","research_integrity","insufficient_payload"],"consensus_categories":["sts","research_integrity","insufficient_payload"],"category_scores_codex":[0.01178317,0.001209724,0.001782171,0.002785175,0.002594535,0.0006769612,0.002932454,0.002349056,0.01271695],"category_scores_gemma":[0.006163535,0.001168007,0.0005162961,0.001862748,0.003574849,0.0002039266,0.009675236,0.01278052,0.003896366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001774142,"about_ca_system_score_gemma":0.005498294,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007883213,"about_ca_topic_score_gemma":0.001057581,"domain_scores_codex":[0.981509,0.00719262,0.00135903,0.003676319,0.0019941,0.004268888],"domain_scores_gemma":[0.9887958,0.003850384,0.0003101504,0.002615869,0.002330616,0.002097189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001825394,0.001510893,0.0003699474,0.01437748,0.0007963688,0.001546846,0.00432325,0.0000960615,0.3622166,0.06956499,0.5362026,0.007169553],"study_design_scores_gemma":[0.003782558,0.002738325,0.0006934459,0.0007850112,0.00007749646,0.0001048417,0.004806721,0.0004076136,0.02753085,0.0338242,0.9236193,0.001629594],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1696576,0.2118785,0.08829908,0.2306869,0.02039501,0.07505585,0.04100192,0.007760256,0.1552649],"genre_scores_gemma":[0.9392279,0.008938215,0.001158743,0.0006362954,0.0007482168,0.001477905,0.004084884,0.0004185726,0.0433092],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7695704,"threshold_uncertainty_score":0.9991369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1020970876518678,"score_gpt":0.3790302474011135,"score_spread":0.2769331597492457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}