{"id":"W4213162889","doi":"10.21203/rs.3.rs-30934/v3","title":"COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; U.S. Air Force; Defense Advanced Research Projects Agency; Defense Threat Reduction Agency; Advanced Research Projects Agency; U.S. Department of Defense","keywords":"Histamine; Famotidine; Mast cell; Coronavirus disease 2019 (COVID-19); Mechanism (biology); Pandemic; Immunology; Mechanism of action; Dysfunctional family; Histamine H2 receptor; Medicine; Receptor; Disease; Biology; Pharmacology; Internal medicine; Infectious disease (medical specialty); Antagonist; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007432299,0.0005167178,0.0003840711,0.0005408005,0.000289917,0.000777466,0.0003674711,0.0009497874,0.006449871],"category_scores_gemma":[0.0002900107,0.0001291131,0.0002321946,0.0003338413,0.0006100153,0.0008747277,0.000488311,0.0005541291,0.001304315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005301625,"about_ca_system_score_gemma":0.0002655529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000473873,"about_ca_topic_score_gemma":0.0002551562,"domain_scores_codex":[0.9998389,0.00003613228,0.00001163911,0.00003400204,0.00005118573,0.00002804201],"domain_scores_gemma":[0.999838,0.00003169097,0.00004566368,0.00001446901,0.00002689082,0.0000432288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003738581,0.0003852429,0.005816576,0.002788342,0.0001539402,0.005823786,0.0002302966,0.001157981,0.8064181,0.02628933,0.0131992,0.1339987],"study_design_scores_gemma":[0.0005219154,0.003283669,0.08155967,0.0007750072,0.0002655757,0.01648987,0.0006629038,0.008939171,0.6274839,0.0528867,0.2070263,0.0001054209],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5141572,0.3506453,0.03937799,0.03118623,0.004055348,0.0002781756,0.002368112,0.001027898,0.05690372],"genre_scores_gemma":[0.9233093,0.03865669,0.007561584,0.00125885,0.001703854,0.00006211823,0.0008958629,0.00004399208,0.02650775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006449871,"threshold_uncertainty_score":0.021577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1020970876518678,"score_gpt":0.3790302474011135,"score_spread":0.2769331597492457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}