{"id":"W4213168715","doi":"10.3390/cells11040707","title":"Aryl Hydrocarbon Receptor (AhR) Limits the Inflammatory Responses in Human Lung Adenocarcinoma A549 Cells via Interference with NF-κB Signaling","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Ministerstvo Zemědělství; Consejo Nacional de Ciencia y Tecnología; Akademie Věd České Republiky; Grantová Agentura České Republiky","keywords":"Aryl hydrocarbon receptor; A549 cell; Inflammation; Chemistry; NF-κB; Proinflammatory cytokine; Cell biology; Cancer research; Immunology; Biology; Cell; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004116051,0.000399542,0.0004788995,0.0002665696,0.000273591,0.0004619043,0.000291063,0.0003485896,0.002427896],"category_scores_gemma":[0.000141214,0.0001996147,0.0006202804,0.0002838579,0.0002838241,0.0002080612,0.000353547,0.0008986404,0.000728663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001875839,"about_ca_system_score_gemma":0.000411791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000909279,"about_ca_topic_score_gemma":0.001014575,"domain_scores_codex":[0.9993874,0.0001005625,0.00008956091,0.00009192503,0.0001823648,0.0001480637],"domain_scores_gemma":[0.999905,0.00002090921,0.00001878816,0.00001878045,0.00001393881,0.00002255878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001326289,0.00009233124,0.0001022489,0.00006594459,0.000007902162,0.00003390592,0.00002213648,0.00004006954,0.9983143,0.00007253883,0.00008268804,0.001033496],"study_design_scores_gemma":[0.00007444843,0.001263707,0.003018845,0.0000184996,0.00003531782,0.0002577851,0.0001012462,0.001108011,0.9856902,0.00007003854,0.008353055,0.00000872109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772559,0.008484166,0.007757978,0.0004141741,0.0003367398,0.000138373,0.0008956097,0.0002696401,0.004447425],"genre_scores_gemma":[0.985473,0.004143319,0.003851352,0.000177976,0.00003642638,0.0001946844,0.001071716,0.00002675054,0.005024862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002427896,"threshold_uncertainty_score":0.008122146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109229249759683,"score_gpt":0.2303344134547538,"score_spread":0.219242120957157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}