{"id":"W4213176808","doi":"10.1016/j.clgc.2022.02.004","title":"Comprehensive genomic profiling of treatment resistant metastatic castrate sensitive prostate cancer reveals high frequency of potential therapeutic targets","year":2022,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University Health Network; Princess Margaret Cancer Centre; McMaster University","funders":"","keywords":"Medicine; Prostate cancer; Androgen receptor; Oncology; Internal medicine; Androgen deprivation therapy; Cohort; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273125,0.0001477838,0.0003321312,0.000526082,0.000170982,0.0004568486,0.0001243401,0.0002221857,0.001641221],"category_scores_gemma":[0.0004790054,0.0001077841,0.0001729109,0.0006380624,0.0001487602,0.0001073919,0.0001935214,0.000320008,0.0002713845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645028,"about_ca_system_score_gemma":0.0001951026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009121434,"about_ca_topic_score_gemma":0.001943985,"domain_scores_codex":[0.9998135,0.000020372,0.000007862295,0.00005201948,0.00007405236,0.00003222133],"domain_scores_gemma":[0.9997873,0.0000674006,0.00006271131,0.00002259822,0.0000298738,0.00003017545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009751898,0.00006395967,0.1448421,0.0002994656,0.0002618415,0.0004762113,0.0002162915,0.001543025,0.7880316,0.00059053,0.001983397,0.06071647],"study_design_scores_gemma":[0.00002282463,0.0004656438,0.9444718,0.00002173458,0.0002585453,0.002470506,0.0002075787,0.002011919,0.040817,0.0005607127,0.008676333,0.00001539736],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857151,0.005025252,0.002232655,0.0003059521,0.00001699017,0.00001750699,0.004470712,0.0001053152,0.002110422],"genre_scores_gemma":[0.9944428,0.000896071,0.000678575,0.0001449242,0.00001429442,0.0000134157,0.002893602,0.00002090194,0.0008953872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001641221,"threshold_uncertainty_score":0.005490422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08870405857679521,"score_gpt":0.4009593395729797,"score_spread":0.3122552809961845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}