{"id":"W4213185838","doi":"10.1016/j.oraloncology.2022.105770","title":"Combined Pik3ca-H1047R and loss-of-function Notch1 alleles decrease survival time in a 4-nitroquinoline N-oxide-driven head and neck squamous cell carcinoma model","year":2022,"lang":"en","type":"letter","venue":"Oral Oncology","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Dental and Craniofacial Research; American Cancer Society","keywords":"4-Nitroquinoline 1-oxide; Head and neck squamous-cell carcinoma; Basal cell; Head and neck; Allele; Medicine; Function (biology); Cancer research; Head and neck cancer; Oncology; Internal medicine; Biology; Genetics; Cancer; Carcinogenesis; Surgery; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002364504,0.0004237391,0.001417001,0.0003706165,0.00007012198,0.00001246678,0.0001333697,0.0007299172,0.0006327577],"category_scores_gemma":[0.00002935192,0.0004127685,0.000136155,0.0001780451,0.0001697695,0.00005812976,0.0001785269,0.001305451,0.000006363734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003825628,"about_ca_system_score_gemma":0.000716628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002116073,"about_ca_topic_score_gemma":0.0006763614,"domain_scores_codex":[0.9977652,0.000229225,0.0005607051,0.0006448702,0.0003171922,0.0004828387],"domain_scores_gemma":[0.998872,0.0001872415,0.0003052297,0.0003431953,0.00009587946,0.0001965006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1069211,0.008232603,0.08026122,0.005958638,0.001098645,0.02825354,0.004011349,0.001910574,0.07835291,0.001752796,0.6508628,0.03238393],"study_design_scores_gemma":[0.1157637,0.07757658,0.02890831,0.0003452053,0.002641823,0.001255719,0.0003642749,0.07905742,0.001155747,0.007772887,0.6819604,0.003197957],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9437683,0.001081785,0.0001187484,0.05318687,0.0003253183,0.0008487639,0.0001497996,0.00004524987,0.0004751234],"genre_scores_gemma":[0.8864695,0.0004093121,0.001717069,0.107379,0.0006243167,0.000146095,0.001111467,0.0001362135,0.00200697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07719716,"threshold_uncertainty_score":0.9998324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02578267696859678,"score_gpt":0.2795628391852693,"score_spread":0.2537801622166725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}