{"id":"W4213192169","doi":"10.2340/actadv.v102.1993","title":"Safety of Brodalumab in Plaque Psoriasis: Integrated Pooled Data from Five Clinical Trials","year":2022,"lang":"en","type":"review","venue":"Acta Dermato Venereologica","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; LEO Pharma; Medac; XBiotech; Swedish Orphan Biovitrum; Fresenius Medical Care North America; Dermira; UCB Pharma; Sun Pharma; Regeneron Pharmaceuticals; Samsung; Valeant Pharmaceuticals International; Sanofi; Celgene; Biogen; GlaxoSmithKline; Amgen; Pfizer; Galderma; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Adverse effect; Ustekinumab; Placebo; Internal medicine; Adalimumab; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008318213,0.001359207,0.006325848,0.003134327,0.0002013036,0.001835116,0.001034278,0.001036553,0.00341727],"category_scores_gemma":[0.01012367,0.0004822989,0.005785455,0.003536614,0.0002684652,0.0007879283,0.0007216088,0.001118886,0.000513739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008357601,"about_ca_system_score_gemma":0.001673889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008129528,"about_ca_topic_score_gemma":0.002060233,"domain_scores_codex":[0.9972571,0.0009817401,0.0006876474,0.0003321528,0.0006347979,0.0001066063],"domain_scores_gemma":[0.9937049,0.003709165,0.001390768,0.0001884163,0.000869384,0.0001373568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007527826,0.000119827,0.002761434,0.3552601,0.07515628,0.0001669951,0.000115283,0.0009469721,0.001818372,0.0005020892,0.008548358,0.5470765],"study_design_scores_gemma":[0.008696365,0.006180288,0.03632606,0.1243324,0.6008793,0.002015291,0.0002480624,0.0008681532,0.004193357,0.002062135,0.2139808,0.0002178777],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001366315,0.9971189,0.0002877628,0.0001066477,0.00008379966,0.0001083037,0.0004099204,0.00001598152,0.0005023235],"genre_scores_gemma":[0.02176164,0.9752129,0.0008318379,0.0004040372,0.0001593374,0.0002187524,0.001103441,0.00001582755,0.0002921301],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008318213,"threshold_uncertainty_score":0.04399145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2406111113496134,"score_gpt":0.4076051418125518,"score_spread":0.1669940304629384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}