{"id":"W4213192169","doi":"10.2340/actadv.v102.1993","title":"Safety of Brodalumab in Plaque Psoriasis: Integrated Pooled Data from Five Clinical Trials","year":2022,"lang":"en","type":"review","venue":"Acta Dermato Venereologica","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; LEO Pharma; Medac; XBiotech; Swedish Orphan Biovitrum; Fresenius Medical Care North America; Dermira; UCB Pharma; Sun Pharma; Regeneron Pharmaceuticals; Samsung; Valeant Pharmaceuticals International; Sanofi; Celgene; Biogen; GlaxoSmithKline; Amgen; Pfizer; Galderma; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Adverse effect; Ustekinumab; Placebo; Internal medicine; Adalimumab; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004892731,0.0009308838,0.007733698,0.0004141718,0.0001800054,0.0000212343,0.002817037,0.002149097,0.008481857],"category_scores_gemma":[0.004207833,0.0006587176,0.001289738,0.0006634187,0.0003173814,0.000145566,0.00153643,0.001518121,0.0004335781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897664,"about_ca_system_score_gemma":0.0008359919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00054913,"about_ca_topic_score_gemma":0.0001398503,"domain_scores_codex":[0.9762552,0.01694247,0.004517413,0.00153034,0.0001198518,0.0006347269],"domain_scores_gemma":[0.9826397,0.01241092,0.002704463,0.002136902,0.00004149832,0.00006650349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000990299,0.0008408547,0.0002651679,0.0005249487,0.005345156,0.0001452163,0.00008572515,4.655519e-7,0.00002292061,0.00008479234,0.01828879,0.9734057],"study_design_scores_gemma":[0.003710992,0.0001433766,0.0002784491,0.001649048,0.004946866,0.000106458,0.0001569611,0.000002324731,0.00003512728,0.0001232421,0.988252,0.0005951879],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001717711,0.9813552,0.000005662071,0.0001011506,0.002215981,0.001520316,0.01243864,0.0001115342,0.0005338279],"genre_scores_gemma":[0.001984602,0.9481229,0.0001393681,0.0001155863,0.0001482331,0.0003038003,0.04866868,0.00006410851,0.0004527828],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9728105,"threshold_uncertainty_score":0.9995864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2406111113496134,"score_gpt":0.4076051418125518,"score_spread":0.1669940304629384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}