{"id":"W4213205915","doi":"10.1101/2022.02.17.480813","title":"A new insight into MYC action: control of RNA polymerase II methylation and transcription termination","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Associazione Italiana per la Ricerca sul Cancro; University of Toronto","keywords":"RNA polymerase II; Transcription (linguistics); Biology; Promoter; Cell biology; Gene; Gene expression; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003169482,0.0003194289,0.0003226554,0.0002365731,0.0001840612,0.00004236232,0.0001696938,0.0005092736,0.00006233347],"category_scores_gemma":[0.00006170944,0.0003906435,0.000129196,0.0002512841,0.00006038562,0.00002268216,0.0001717121,0.0003084588,9.552404e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001704202,"about_ca_system_score_gemma":0.0005045549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001321156,"about_ca_topic_score_gemma":0.00001305324,"domain_scores_codex":[0.9982129,0.0001752723,0.0004552816,0.0006787635,0.0002845587,0.0001932461],"domain_scores_gemma":[0.9985734,0.00001225492,0.0004757918,0.0005804746,0.0002266531,0.0001314556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001789761,0.00005024257,0.0002844731,0.0001465552,0.0001512667,0.00000139943,0.00004511387,0.0006301359,0.9980711,0.00006745251,0.00009166232,0.0002815934],"study_design_scores_gemma":[0.001198168,0.0002208031,0.01685461,0.00006343019,0.000193967,4.796639e-8,0.000003722852,0.0007955718,0.9707113,0.000004671841,0.009567113,0.0003866194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599295,0.006423149,0.03152161,0.0003099815,0.0009609292,0.0006922889,0.00009615221,0.00005715592,0.000009247824],"genre_scores_gemma":[0.9969849,0.0007365483,0.001483056,0.00005712396,0.0005323871,0.0001045634,0.000009246211,0.00006436318,0.00002780612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03705542,"threshold_uncertainty_score":0.9998546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009188294621786256,"score_gpt":0.2307899617251771,"score_spread":0.2216016671033909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}