{"id":"W4213205915","doi":"10.1101/2022.02.17.480813","title":"A new insight into MYC action: control of RNA polymerase II methylation and transcription termination","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Associazione Italiana per la Ricerca sul Cancro; University of Toronto","keywords":"RNA polymerase II; Transcription (linguistics); Biology; Promoter; Cell biology; Gene; Gene expression; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002802887,0.0003993088,0.0004179864,0.0002977673,0.0001866989,0.0006067979,0.000459438,0.0005463257,0.00190732],"category_scores_gemma":[0.0001321138,0.0001826745,0.0003088067,0.0001529714,0.0005346837,0.0009682591,0.0003053795,0.0009367557,0.0004008766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000453041,"about_ca_system_score_gemma":0.0001783619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001752603,"about_ca_topic_score_gemma":0.0003118026,"domain_scores_codex":[0.9998794,0.00001510414,0.000008198488,0.00004333916,0.00002821004,0.00002568985],"domain_scores_gemma":[0.9998996,0.00002203297,0.00002369119,0.00001294395,0.00001660056,0.00002507367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002421458,0.00003356747,0.0005594317,0.0002422701,0.00001263189,0.0002053658,0.00005354836,0.0003279811,0.9753134,0.007213355,0.0003315954,0.01546466],"study_design_scores_gemma":[0.00008890245,0.001089259,0.01589652,0.0001547557,0.00008192335,0.001844608,0.0002932157,0.0138278,0.8711263,0.02177333,0.07376241,0.00006105971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6282492,0.2228637,0.1059423,0.01208366,0.001613405,0.00007389935,0.000921783,0.0006776832,0.02757428],"genre_scores_gemma":[0.9439254,0.03437582,0.009820175,0.001138849,0.0007845516,0.00003440992,0.0002303703,0.00006934104,0.009620919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00190732,"threshold_uncertainty_score":0.006380618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009188294621786256,"score_gpt":0.2307899617251771,"score_spread":0.2216016671033909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}