{"id":"W4213216277","doi":"10.1200/jco.2022.40.6_suppl.308","title":"Characterizing IMDC prognostic groups in contemporary first-line combination therapies for metastatic renal cell carcinoma (mRCC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Juravinski Cancer Centre; McMaster University; London Health Sciences Centre; Western University; University of Alberta; Queen Elizabeth II Health Sciences Centre; Dalhousie University; University of Calgary","funders":"","keywords":"Medicine; Pazopanib; Axitinib; Sunitinib; Nivolumab; Internal medicine; Pembrolizumab; Oncology; Ipilimumab; Renal cell carcinoma; Interquartile range; Cabozantinib; Context (archaeology); Bevacizumab; Everolimus; Clinical endpoint; Vascular endothelial growth factor; Clinical trial; Cancer; Immunotherapy; Chemotherapy; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002244927,0.0002152119,0.0004897682,0.002200407,0.0003091189,0.0008417912,0.0004853718,0.0003279161,0.001413798],"category_scores_gemma":[0.007115918,0.00009238799,0.0003513329,0.002811661,0.0001918653,0.0005701997,0.0007243821,0.0003595685,0.0003766212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007873909,"about_ca_system_score_gemma":0.0007069909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002216009,"about_ca_topic_score_gemma":0.00316721,"domain_scores_codex":[0.9985271,0.0003014815,0.0003090837,0.0002615957,0.0004256606,0.0001750343],"domain_scores_gemma":[0.9927939,0.001240396,0.004495635,0.0002811554,0.0006835698,0.0005052677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004789145,0.00002462343,0.990497,0.0000320566,0.00003165739,0.00003958137,0.00003037652,0.000168279,0.0001247919,0.00004514243,0.0004876,0.008039968],"study_design_scores_gemma":[0.00005317141,0.000268706,0.9934278,0.00002662372,0.00008413271,0.0006842359,0.0001748655,0.002462482,0.0003579847,0.00009560499,0.002358232,0.000006108606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893963,0.001906182,0.0006206004,0.0001880506,0.00001415351,0.0001027792,0.005556171,0.00002182546,0.00219407],"genre_scores_gemma":[0.9941379,0.0001750696,0.0006087338,0.00003517605,0.00001792677,0.00005777089,0.004868377,0.000005466328,0.00009357085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002244927,"threshold_uncertainty_score":0.01187247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1915511936796025,"score_gpt":0.4126998431412933,"score_spread":0.2211486494616907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}