{"id":"W4213217351","doi":"10.1039/d1bm01684a","title":"Self-immolative polyplexes for DNA delivery","year":2022,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Ontario","keywords":"Chemistry; DNA; Biophysics; Nanotechnology; Biochemistry; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004878814,0.0001060714,0.0001007671,0.00007504503,0.0005168743,0.00007269967,0.0005125176,0.0000298962,0.00008202006],"category_scores_gemma":[0.00004048069,0.0001012736,0.00005759779,0.0001660749,0.0001668133,0.00001128967,0.0003997914,0.00001154586,0.00001167041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003454312,"about_ca_system_score_gemma":0.0002220758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001742167,"about_ca_topic_score_gemma":0.000002884015,"domain_scores_codex":[0.9989081,0.000041003,0.0001603249,0.0004088365,0.0001896302,0.0002921244],"domain_scores_gemma":[0.9994982,0.000008621656,0.0000804141,0.0002521175,0.0001008315,0.00005984018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009132698,0.00003633771,0.0001124558,0.000006526503,0.0000103222,9.290844e-7,0.00008200118,0.000007638216,0.998001,0.00009968026,0.001329272,0.0002225045],"study_design_scores_gemma":[0.0002050745,0.0005447515,0.0005953479,0.00000194196,0.000006761333,0.00001577539,0.0001662528,0.00008323812,0.9759108,0.00007942442,0.02224006,0.0001505546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979423,0.0001733112,0.0002417891,0.00007283803,0.0008486443,0.0002457979,0.0001696714,0.0000254358,0.0002801702],"genre_scores_gemma":[0.997178,0.00002122572,0.001927833,0.0002851218,0.0001628937,0.0001286989,0.00004997049,0.000009894244,0.0002363894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02209018,"threshold_uncertainty_score":0.4129816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286240092547684,"score_gpt":0.2586554138751371,"score_spread":0.2457930129496603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}