{"id":"W4213217351","doi":"10.1039/d1bm01684a","title":"Self-immolative polyplexes for DNA delivery","year":2022,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Ontario","keywords":"Chemistry; DNA; Biophysics; Nanotechnology; Biochemistry; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001962594,0.0003148636,0.0001279394,0.0001647255,0.00009421306,0.000250043,0.0001641847,0.0002922225,0.0008607825],"category_scores_gemma":[0.0002286974,0.0001289796,0.0001377299,0.0001033951,0.000149395,0.0002870839,0.0001724421,0.0005236526,0.0003639783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787925,"about_ca_system_score_gemma":0.0001649997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001421548,"about_ca_topic_score_gemma":0.0003222297,"domain_scores_codex":[0.9998806,0.0000202353,0.00001225298,0.00003664985,0.00003318565,0.00001711397],"domain_scores_gemma":[0.9998617,0.00003680134,0.00004680504,0.00001151114,0.00001298334,0.0000301274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000183848,0.00001186513,0.00002251032,0.00002756789,0.000003257615,0.00001757983,0.000009840881,0.00007930846,0.9978649,0.000168821,0.0000279847,0.001747997],"study_design_scores_gemma":[0.000004900963,0.00008945881,0.0001497122,0.000002365006,0.000004612775,0.00005459243,0.000002187498,0.0005154658,0.9971386,0.00002500816,0.0020106,0.000002572621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571165,0.003179673,0.03531181,0.000174849,0.0001078937,0.0001192931,0.0001974354,0.0002670139,0.00352552],"genre_scores_gemma":[0.9747653,0.001016074,0.01746492,0.0001063254,0.00002491243,0.00007823276,0.0002740505,0.00004896521,0.00622113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008607825,"threshold_uncertainty_score":0.00287962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286240092547684,"score_gpt":0.2586554138751371,"score_spread":0.2457930129496603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}