{"id":"W4213223108","doi":"10.1200/jco.2022.40.6_suppl.060","title":"Treatment outcomes for metastatic castration-resistant prostate cancer (mCRPC) following progression on upfront androgen deprivation therapy (ADT) with androgen receptor pathway inhibitors (ARPI) for metastatic castration-sensitive prostate cancer (mCSPC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Abbotsford Veterinary Clinic; BC Cancer Agency; Kelowna General Hospital; University of British Columbia","funders":"BC Cancer Foundation","keywords":"Medicine; Enzalutamide; Prostate cancer; Internal medicine; Docetaxel; Oncology; Androgen deprivation therapy; Proportional hazards model; Abiraterone acetate; Progression-free survival; Cancer; Chemotherapy; Androgen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004470626,0.0001560422,0.0002930047,0.000555931,0.0003437503,0.0004619602,0.0002905426,0.000253288,0.001007789],"category_scores_gemma":[0.001229716,0.0001100181,0.000357328,0.0008115624,0.0002556645,0.0002580401,0.000373868,0.0004483539,0.0001542301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001158662,"about_ca_system_score_gemma":0.0007049805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01313669,"about_ca_topic_score_gemma":0.02880291,"domain_scores_codex":[0.9996773,0.00005117404,0.00003396148,0.00005841295,0.00009457444,0.00008453363],"domain_scores_gemma":[0.9988582,0.000131856,0.0006497899,0.00003813772,0.00008028101,0.0002417408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007316435,0.00005184469,0.9946415,0.00002576047,0.00005213389,0.0002077505,0.00008385726,0.0001036931,0.0002404218,0.0000115101,0.0001629953,0.003686816],"study_design_scores_gemma":[0.00002493439,0.0003161046,0.9986292,0.000008029464,0.00004785054,0.0004598245,0.00006574757,0.0001367124,0.00007346412,0.00001803204,0.0002161553,0.000003943809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987867,0.0003347672,0.00003039177,0.00003102074,0.00000271922,0.00001445751,0.0005656679,0.000002119739,0.0002321203],"genre_scores_gemma":[0.9991068,0.00007811616,0.0000221037,0.00001028094,0.000004304973,0.000006112016,0.0007017035,6.859742e-7,0.00006986891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01313669,"threshold_uncertainty_score":0.02612042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1347731095972081,"score_gpt":0.4716707362161949,"score_spread":0.3368976266189868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}