{"id":"W4213232225","doi":"10.1101/2022.02.20.22271237","title":"At Least Three Doses of Leading Vaccines Essential for Neutralisation of SARS-CoV-2 Omicron Variant","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Medical Research Council; U.S. Food and Drug Administration; Barwon Health Foundation; National Health and Medical Research Council; State Government of Victoria; Department of Health, State Government of Victoria; Commonwealth Scientific and Industrial Research Organisation; U.S. Department of Health and Human Services","keywords":"Neutralization; Virology; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Antibody; Medicine; Virus; Disease; Immunology; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008246939,0.0003848693,0.0007305733,0.0001438862,0.0002059181,0.0004546549,0.0003188821,0.0007749866,0.002499418],"category_scores_gemma":[0.0008187796,0.0001832014,0.0003551724,0.0001508371,0.0002188806,0.0003085033,0.0001974582,0.0009687767,0.0005072088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003933374,"about_ca_system_score_gemma":0.0004752802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007532767,"about_ca_topic_score_gemma":0.0009686046,"domain_scores_codex":[0.9993099,0.0001850776,0.0000649859,0.0001031728,0.0001610966,0.0001757906],"domain_scores_gemma":[0.9996351,0.00009149672,0.00006428396,0.00006616093,0.00007986218,0.00006321476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008879025,0.002758719,0.008065626,0.0002147376,0.0001070667,0.0001941179,0.0002046256,0.0008068715,0.9485885,0.000267551,0.002003697,0.02790947],"study_design_scores_gemma":[0.001116412,0.08483563,0.08052842,0.00006817692,0.0002061667,0.001148365,0.0001921066,0.001923628,0.8114764,0.0002444203,0.01822498,0.00003530195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941242,0.0009488572,0.001636734,0.0001709916,0.0001612131,0.0004205917,0.0006101395,0.0001053031,0.001821986],"genre_scores_gemma":[0.9930637,0.0002441971,0.002178543,0.0002539446,0.00005218107,0.0002700026,0.001443933,0.00001717319,0.002476217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002499418,"threshold_uncertainty_score":0.008361459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09295734143528309,"score_gpt":0.3796257098332776,"score_spread":0.2866683683979946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}