{"id":"W4213235126","doi":"10.1093/jcag/gwab049.183","title":"A184 REPURPOSING DRUGS FOR SPLEEN TYROSINE KINASE (SYK) PEDIATRIC PATIENTS USING HIGH-THROUGHPUT SCREENING","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Syk; HEK 293 cells; Phosphorylation; Cancer research; Phenotype; Tyrosine phosphorylation; Tyrosine kinase; Cell biology; Signal transduction; Biology; Receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005272007,0.0007027056,0.00103665,0.0008832975,0.0002773757,0.0009634651,0.0004884057,0.0005166449,0.002225906],"category_scores_gemma":[0.0003933363,0.0002581511,0.0008314141,0.0007366834,0.0001458049,0.0003051028,0.0003923519,0.0006116626,0.0007465752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006309039,"about_ca_system_score_gemma":0.0005959884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000865964,"about_ca_topic_score_gemma":0.00252347,"domain_scores_codex":[0.9996758,0.00005454859,0.00001850731,0.00005817653,0.0001452199,0.00004775145],"domain_scores_gemma":[0.9998214,0.00004575123,0.0000367311,0.00001618063,0.00005002041,0.00002990446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001596185,0.001753861,0.01333536,0.001224716,0.0005829173,0.001031254,0.00007812597,0.009647524,0.8093821,0.001198733,0.008718112,0.1514511],"study_design_scores_gemma":[0.0006538477,0.007573905,0.03336928,0.0001477513,0.001363087,0.003757042,0.0001692025,0.04544204,0.854827,0.001210001,0.05135037,0.0001365382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9076498,0.03062596,0.03472168,0.00193865,0.0002025944,0.001679186,0.01147841,0.001975999,0.009727793],"genre_scores_gemma":[0.9244465,0.01561131,0.04069131,0.0007397997,0.00006794133,0.0007204956,0.009523949,0.0001040544,0.008094611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002225906,"threshold_uncertainty_score":0.007446408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820836042361701,"score_gpt":0.2706454146964261,"score_spread":0.252437054272809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}