{"id":"W4213245018","doi":"10.1093/jcag/gwab049.004","title":"A5 GLUTEN-SPECIFIC T CELL ACTIVATION BY MHC CLASS II EXPRESSING ORGANOID MONOLAYERS","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"","keywords":"Organoid; MHC class I; Cell biology; Monolayer; MHC class II; Chemistry; Major histocompatibility complex; Molecular biology; Biology; Immunology; Antigen; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294102,0.0005511866,0.0002775273,0.0002739248,0.0002676992,0.0004968466,0.0002458629,0.0004546136,0.008586354],"category_scores_gemma":[0.0001824169,0.0001423797,0.0004020862,0.0003314599,0.0001172224,0.0002623184,0.0002241578,0.001026715,0.001854665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786894,"about_ca_system_score_gemma":0.0002060188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00169321,"about_ca_topic_score_gemma":0.001739395,"domain_scores_codex":[0.9996301,0.00008038152,0.00003400074,0.0000755941,0.00005785358,0.000122207],"domain_scores_gemma":[0.9998516,0.0000734267,0.00001410053,0.00001955602,0.00002083129,0.0000204577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006823772,0.00009131534,0.0001132246,0.00005839407,0.000008603365,0.00007032185,0.00005611426,0.0001447834,0.9971846,0.0001237874,0.000301177,0.001165387],"study_design_scores_gemma":[0.00009538139,0.001020291,0.003784968,0.00001745968,0.00002994404,0.0001060466,0.0001503901,0.001631905,0.9897225,0.0000694974,0.003364384,0.000007152199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821517,0.0006827301,0.002313342,0.0001792004,0.0002578791,0.00009285478,0.001479342,0.00008502586,0.01275784],"genre_scores_gemma":[0.9844812,0.0006110357,0.002585929,0.000159629,0.0000624897,0.00007232863,0.002312415,0.00003466767,0.009680413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008586354,"threshold_uncertainty_score":0.02872419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006006348931091617,"score_gpt":0.186372171513557,"score_spread":0.1803658225824654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}