{"id":"W4213248386","doi":"10.1186/s40463-022-00558-w","title":"Introduction and expression of <i>PIK3CA</i><sup>E545K</sup> in a papillary thyroid cancer <i>BRAF</i><sup>V600E</sup> cell line leads to a dedifferentiated aggressive phenotype","year":2022,"lang":"en","type":"article","venue":"Journal of Otolaryngology - Head and Neck Surgery","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Institute of Cancer Research; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Phenotype; Papillary thyroid cancer; Expression (computer science); Cancer research; Thyroid cancer; Cancer; Biology; Medicine; Genetics; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001989956,0.0003566896,0.0002841365,0.0002478482,0.0002457438,0.0003996887,0.0004466365,0.0005813653,0.001905388],"category_scores_gemma":[0.000133882,0.0002672745,0.0004470428,0.0003224104,0.0003994592,0.000179605,0.0003074859,0.0007808521,0.0006650872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005489157,"about_ca_system_score_gemma":0.0004087626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002473955,"about_ca_topic_score_gemma":0.002394124,"domain_scores_codex":[0.9995613,0.00004867896,0.00007294319,0.00007915448,0.0001161198,0.0001217417],"domain_scores_gemma":[0.9998134,0.00003703011,0.00004858575,0.00003979752,0.00001415698,0.00004699107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009325711,0.00005167893,0.0001800332,0.00002238858,0.000007099808,0.00007336496,0.00002275603,0.00007353713,0.9986594,0.0001499156,0.0000880021,0.0005784806],"study_design_scores_gemma":[0.00004366827,0.0009055168,0.004480057,0.000006780792,0.0000357893,0.0004534248,0.00005717871,0.001237853,0.9873663,0.00004644466,0.005356458,0.00001053616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931612,0.0004433957,0.002000264,0.0001386024,0.0000657643,0.000102164,0.001304006,0.0001605314,0.00262409],"genre_scores_gemma":[0.9878321,0.000337505,0.003410018,0.00009180284,0.00001444418,0.0001421862,0.002192152,0.00005390438,0.005925819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002473955,"threshold_uncertainty_score":0.006374121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193580292480297,"score_gpt":0.2468514672608619,"score_spread":0.2349156643360589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}