{"id":"W4213248759","doi":"10.1016/j.freeradbiomed.2021.12.242","title":"Effect of APOE ε4 Allele on Levels of Apolipoproteins E, J, and D, and Redox Signature In Circulating Extracellular Vesicles from Cognitively Impaired with No Dementia Participants Converted to Alzheimer’s Disease","year":2022,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Institut National de la Recherche Scientifique","funders":"","keywords":"Extracellular vesicles; Apolipoprotein E; Allele; Dementia; Redox; Extracellular; Microvesicles; Disease; Neuroscience; Medicine; Chemistry; Biology; Internal medicine; Biochemistry; Cell biology; Gene; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002340001,0.0003541891,0.0003558031,0.0003462827,0.0003657872,0.000623634,0.000221894,0.0004338579,0.00181767],"category_scores_gemma":[0.0009725856,0.000215432,0.0003036657,0.0002135102,0.000238078,0.0003083769,0.0002793523,0.0005039145,0.0002196085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00017366,"about_ca_system_score_gemma":0.0001418177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004094106,"about_ca_topic_score_gemma":0.002670748,"domain_scores_codex":[0.9998639,0.00002322336,0.00001717587,0.0000482479,0.0000166711,0.00003082416],"domain_scores_gemma":[0.9996523,0.00008866754,0.00008036108,0.00002619533,0.00006188958,0.00009074219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0544364,0.00147905,0.8587665,0.0001191154,0.0008298941,0.001558916,0.002121316,0.000122879,0.06791352,0.0001689742,0.0003561117,0.01212729],"study_design_scores_gemma":[0.00008366476,0.001569802,0.9936746,0.0000099228,0.0003236433,0.0005198647,0.0006653507,0.0002401066,0.002490956,0.0001330281,0.0002734916,0.00001554361],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996612,0.00008568291,0.00001931912,0.00001129166,0.000006507396,0.0000017713,0.00006222167,0.000001162818,0.0001508567],"genre_scores_gemma":[0.9992084,0.00003338987,0.0000301705,0.00001639613,0.000004006022,0.000002896162,0.00009806941,0.000001656678,0.0006049368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004094106,"threshold_uncertainty_score":0.008140504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01593636689551833,"score_gpt":0.2799337285435382,"score_spread":0.2639973616480199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}