{"id":"W4213259208","doi":"10.1155/2022/7503553","title":"Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance","year":2022,"lang":"en","type":"article","venue":"Neural Plasticity","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development","keywords":"Autophagy; Prefrontal cortex; Microglia; ATG5; Social defeat; FKBP5; ATG12; Psychology; Internal medicine; Endocrinology; Neuroscience; Medicine; Biology; Glucocorticoid; Inflammation; Apoptosis; Glucocorticoid receptor; Biochemistry; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0001529471,0.0002676508,0.0002731642,0.0002143558,0.001421736,0.0001198622,0.0004019345,0.00006772909,0.000352786],"category_scores_gemma":[0.000426013,0.0002958147,0.0001152242,0.0007324559,0.00007469241,0.0001787461,0.0002809396,0.0006827939,0.00005435919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001425509,"about_ca_system_score_gemma":0.00006617214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002112504,"about_ca_topic_score_gemma":0.00003937997,"domain_scores_codex":[0.9968631,0.0006712323,0.0004898099,0.0007669094,0.0006833029,0.0005256225],"domain_scores_gemma":[0.9992366,0.0002589186,0.0002428436,0.000137939,0.00004072233,0.00008294339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001245846,0.0001642842,0.00009843411,0.00001073634,0.000001208602,0.0001531125,0.0005503732,0.002420377,0.9926116,0.003046123,0.0005270775,0.0002921275],"study_design_scores_gemma":[0.0008290072,0.0001463796,0.003546442,0.000002725385,0.000007504471,0.00004052838,0.00008513887,0.01629487,0.9782969,0.0002029674,0.0002774067,0.0002701766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973155,0.000004548769,0.00006816851,0.0007218692,0.0008206785,0.0003524039,0.0001741099,0.0002696927,0.000273064],"genre_scores_gemma":[0.998034,0.000001815403,0.00002002277,0.001378982,0.0001328815,0.00007588889,0.0000162129,0.00003539694,0.0003047958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01431471,"threshold_uncertainty_score":0.9999494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04629870255421944,"score_gpt":0.2676000179167082,"score_spread":0.2213013153624887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}