{"id":"W4213259208","doi":"10.1155/2022/7503553","title":"Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance","year":2022,"lang":"en","type":"article","venue":"Neural Plasticity","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development","keywords":"Autophagy; Prefrontal cortex; Microglia; ATG5; Social defeat; FKBP5; ATG12; Psychology; Internal medicine; Endocrinology; Neuroscience; Medicine; Biology; Glucocorticoid; Inflammation; Apoptosis; Glucocorticoid receptor; Biochemistry; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009559523,0.0004772905,0.0003316234,0.0002848662,0.0002058113,0.0001610716,0.00009784912,0.0002370858,0.0006837362],"category_scores_gemma":[0.00007125737,0.0001682862,0.0003132334,0.00009428478,0.0002492449,0.0000983463,0.0002285283,0.0005451041,0.0001560372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222042,"about_ca_system_score_gemma":0.0001833358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006536436,"about_ca_topic_score_gemma":0.001521867,"domain_scores_codex":[0.9999298,0.00001176495,0.000008621045,0.0000156422,0.00001393538,0.00002030634],"domain_scores_gemma":[0.999936,0.000002287464,0.00002710175,0.000006294183,0.000005264547,0.00002307641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007791329,0.0001709328,0.001754821,0.00006825908,0.00003341075,0.0004215851,0.00006147756,0.00005483207,0.9940044,0.00008603735,0.0001247487,0.002440358],"study_design_scores_gemma":[0.0004953906,0.006202107,0.3744755,0.000121394,0.0003108485,0.007150308,0.0007393725,0.003687715,0.6004363,0.001139021,0.005188533,0.00005352412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986261,0.0004433449,0.0003522354,0.00007442854,0.00001680747,0.00001525831,0.0001284715,0.00002359669,0.0003197694],"genre_scores_gemma":[0.9983054,0.0003858963,0.0004564228,0.00007032641,0.000008797348,0.00003860153,0.0001675039,0.000004610718,0.0005622761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006837362,"threshold_uncertainty_score":0.002287269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04629870255421944,"score_gpt":0.2676000179167082,"score_spread":0.2213013153624887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}