{"id":"W4213261511","doi":"10.1200/jco.2010.28.18_suppl.lba5012b","title":"PRECEDENT: A randomized phase II trial comparing EC145 and pegylated liposomal doxorubicin (PLD) in combination, versus PLD alone, in subjects with platinum-resistant ovarian cancer.","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Interim analysis; Adverse effect; Internal medicine; Ovarian cancer; Oncology; Discontinuation; Randomized controlled trial; Cancer; Urology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001281806,0.001577841,0.001688074,0.000430299,0.0003779862,0.0009393297,0.0008718598,0.001478132,0.009511186],"category_scores_gemma":[0.001295728,0.0006319709,0.001064663,0.0003277683,0.0009220128,0.0009525616,0.0003393317,0.002428416,0.001382204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006640782,"about_ca_system_score_gemma":0.001222193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000751108,"about_ca_topic_score_gemma":0.002576387,"domain_scores_codex":[0.999559,0.0002555151,0.000016579,0.00007143817,0.00003666939,0.00006083655],"domain_scores_gemma":[0.9993415,0.0001475589,0.0001334968,0.00005292642,0.00003131848,0.0002931267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9709274,0.007857497,0.000496134,0.0004275055,0.000347367,0.00005970237,0.00005083092,0.0003294276,0.005315592,0.0001791658,0.001006927,0.01300246],"study_design_scores_gemma":[0.8900729,0.106321,0.001415611,0.00001757364,0.0002269116,0.00003589024,0.0000164268,0.0001929543,0.0004920721,0.0001161447,0.001084194,0.000008157728],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785554,0.004308372,0.0008047476,0.001172301,0.0005004536,0.006658098,0.001804105,0.0002140882,0.005982459],"genre_scores_gemma":[0.9750708,0.002526382,0.002359692,0.001445214,0.0004902764,0.005876293,0.002580773,0.00003387588,0.009616639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009511186,"threshold_uncertainty_score":0.03181803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07929973743231516,"score_gpt":0.439236840127927,"score_spread":0.3599371026956119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}