{"id":"W4213275239","doi":"10.3390/biology11020298","title":"Selective Loss of MATR3 in Spinal Interneurons, Upper Motor Neurons and Hippocampal CA1 Neurons in a MATR3 S85C Knock-In Mouse Model of Amyotrophic Lateral Sclerosis","year":2022,"lang":"en","type":"article","venue":"Biology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Canada Research Chairs; Scottish Rite Charitable Foundation of Canada; ALS Society of Canada","keywords":"Biology; Amyotrophic lateral sclerosis; Spinal cord; Neuroscience; Motor neuron; Deep cerebellar nuclei; Motor cortex; Central nervous system; Cerebellar cortex; Anatomy; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955812,0.0009658934,0.0005548227,0.001046185,0.0004465675,0.0005011026,0.00047556,0.0008874223,0.002315309],"category_scores_gemma":[0.0001261855,0.0005007603,0.0004397474,0.0003465032,0.0006674763,0.0004218955,0.0003589054,0.001305119,0.0007365422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005127713,"about_ca_system_score_gemma":0.0003913722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001870078,"about_ca_topic_score_gemma":0.003980304,"domain_scores_codex":[0.9996573,0.00002143826,0.00004501873,0.0001171883,0.00009342493,0.0000656735],"domain_scores_gemma":[0.9996909,0.00001792511,0.0001234061,0.00002101754,0.00001902804,0.000127683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112072,0.00003963853,0.000133675,0.00003090672,0.000007115213,0.000118531,0.00003140526,0.00004926372,0.9988362,0.00006545724,0.00005053872,0.0005252091],"study_design_scores_gemma":[0.00009573723,0.0006575012,0.01373007,0.00004262494,0.00008122975,0.001709355,0.00009225663,0.001438696,0.9795639,0.0001679594,0.002402232,0.00001839863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897504,0.001470229,0.003648718,0.0002987775,0.00007328481,0.00008996623,0.001637722,0.0004983419,0.002532608],"genre_scores_gemma":[0.9774038,0.001442833,0.006964787,0.0002367051,0.00002747217,0.0001831507,0.001342734,0.0002041974,0.01219432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002315309,"threshold_uncertainty_score":0.007745504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0390500602059017,"score_gpt":0.295350303126158,"score_spread":0.2563002429202563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}