{"id":"W4213279127","doi":"10.1101/2022.02.21.481308","title":"HIV-1 Vpu restricts Fc-mediated effector functions in vivo","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Baden-Württemberg Stiftung; Canadian Institutes of Health Research; Tulane University; Fonds de Recherche du Québec - Santé; Universität zu Köln; Karolinska Institutet; Israel Science Foundation; Deutsche Forschungsgemeinschaft; Burnet Institute; National Institutes of Health; International AIDS Vaccine Initiative","keywords":"Antibody-dependent cell-mediated cytotoxicity; Effector; Virology; Tetherin; Biology; Antibody; Glycoprotein; In vivo; Virus; Downregulation and upregulation; Cell biology; Viral envelope; Immunology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000246937,0.0002882734,0.0002526035,0.0002536345,0.000128112,0.0004337995,0.0002202816,0.0002446036,0.002470789],"category_scores_gemma":[0.0002025846,0.0001412477,0.0001454594,0.00007603494,0.0002145894,0.0001617159,0.0002039055,0.0007828003,0.0009404728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002796628,"about_ca_system_score_gemma":0.0001868663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007365106,"about_ca_topic_score_gemma":0.0004848976,"domain_scores_codex":[0.9998166,0.00003607287,0.00000881095,0.00003404735,0.00004300772,0.00006144928],"domain_scores_gemma":[0.9998217,0.00007716332,0.00001568628,0.00004088993,0.00001459339,0.00002993729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002206643,0.00008059724,0.0002998666,0.00003192333,0.000005240805,0.00004726699,0.00002297376,0.0001270432,0.9948808,0.0005118028,0.0003394212,0.003432337],"study_design_scores_gemma":[0.0000361507,0.0004539962,0.002917016,0.00001686385,0.00001291066,0.000560783,0.00002374738,0.001783381,0.986846,0.0003758155,0.006969938,0.000003529187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798474,0.003373346,0.005136548,0.0003045416,0.00007293999,0.00003360434,0.0003777992,0.0002064093,0.01064744],"genre_scores_gemma":[0.99314,0.0005903494,0.001146005,0.00009405603,0.00003001038,0.00002063101,0.0004891558,0.00004526297,0.004444685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002470789,"threshold_uncertainty_score":0.008265615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301828414510617,"score_gpt":0.2277155599901568,"score_spread":0.2146972758450506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}