{"id":"W4213286840","doi":"10.3390/curroncol29020094","title":"Cell-Free Tumor DNA (ctDNA) Utility in Detection of Original Sensitizing and Resistant EGFR Mutations in Non-Small Cell Lung Cancer (NSCLC)","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"","keywords":"T790M; Medicine; Lung cancer; Internal medicine; Oncology; Mutation; Biomarker; Liquid biopsy; Cell-free fetal DNA; Resistance mutation; Cancer; Gene; Cancer research; Adenocarcinoma; Polymerase chain reaction; Genetics; Reverse transcriptase; Biology; ROS1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001072723,0.0003621256,0.0003955903,0.001004369,0.0001800476,0.0006644394,0.0003235691,0.0006160605,0.001530078],"category_scores_gemma":[0.001795876,0.000216431,0.0001441327,0.0004249397,0.0004491797,0.0002641832,0.0002153805,0.0002819566,0.0003389208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003570362,"about_ca_system_score_gemma":0.0003410458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007941551,"about_ca_topic_score_gemma":0.001723318,"domain_scores_codex":[0.9992325,0.0001940009,0.00004703673,0.0002321626,0.0002463588,0.00004798097],"domain_scores_gemma":[0.9990821,0.0002966832,0.0003356703,0.00004555437,0.000140809,0.00009920702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003517652,0.0003618183,0.6020662,0.0006559686,0.0001576638,0.0005263524,0.0002923073,0.0004293643,0.3096422,0.0001043137,0.0003384502,0.08190773],"study_design_scores_gemma":[0.0002419877,0.01030498,0.8037583,0.0001305485,0.0004943499,0.007447946,0.0002756495,0.002976905,0.1696351,0.0001663107,0.00451291,0.00005501935],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888469,0.006868436,0.00267469,0.00006384304,0.00002949285,0.0001304854,0.0007175906,0.00005685855,0.0006117909],"genre_scores_gemma":[0.9940783,0.001278372,0.003222898,0.00006173867,0.00002148387,0.00006359127,0.0006385883,0.000005991868,0.0006291173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530078,"threshold_uncertainty_score":0.00567317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0219119162515935,"score_gpt":0.3074366635185424,"score_spread":0.2855247472669489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}