{"id":"W4213299631","doi":"10.1016/j.isci.2022.103946","title":"Alteration of lipid bilayer mechanics by volatile anesthetics: Insights from μs-long molecular dynamics simulations","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Lipid bilayer; Chemistry; Biophysics; Transmembrane protein; Molecular dynamics; Phospholipid; Lipid bilayer phase behavior; Bilayer; Membrane; Biochemistry; Computational chemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005093452,0.0001020204,0.00009705403,0.0000402941,0.0001730808,0.00002023675,0.0002629753,0.00004427873,0.00007963194],"category_scores_gemma":[0.00001889372,0.0000983401,0.00005106484,0.0001811917,0.00004724084,0.000007940144,0.00014534,0.00007866469,0.000001209274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002838309,"about_ca_system_score_gemma":0.0001041839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004847026,"about_ca_topic_score_gemma":0.00004949099,"domain_scores_codex":[0.9990838,0.00005040682,0.0001784026,0.0003059929,0.0002506285,0.0001308207],"domain_scores_gemma":[0.9994684,0.000009237207,0.00009598327,0.0003154679,0.00006308762,0.00004781575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009133569,0.00003525448,0.000494702,0.000002249401,0.00000464787,0.000001752018,0.0001110907,0.007303963,0.9910536,0.00028604,0.00004733408,0.0006501848],"study_design_scores_gemma":[0.0002109203,0.0001601172,0.0002874558,0.000002778355,0.00001989444,0.000007007159,0.000068507,0.03568825,0.959846,0.0003294778,0.003220643,0.0001590158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830694,0.0001824249,0.01598142,0.00006929808,0.0002679513,0.0001382525,0.0001964758,0.000008408166,0.00008635405],"genre_scores_gemma":[0.9986451,0.000005642516,0.0004139761,0.0001732446,0.00005283892,0.00001148789,0.000563078,0.00001155153,0.0001230536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03120772,"threshold_uncertainty_score":0.4010193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005529425227432515,"score_gpt":0.2302114675110309,"score_spread":0.2246820422835984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}