{"id":"W4213301132","doi":"10.3390/antiox11020408","title":"Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation","year":2022,"lang":"en","type":"review","venue":"Antioxidants","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":227,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; U.S. Department of Defense","keywords":"Oxidative stress; Antioxidant; Neurodegeneration; Reactive oxygen species; Reactive nitrogen species; Chemistry; Pharmacology; Biochemistry; Oxidative phosphorylation; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002626271,0.0006014555,0.001129716,0.001018376,0.0002463947,0.001585282,0.0006840742,0.002086053,0.003156863],"category_scores_gemma":[0.002028567,0.0002676096,0.0007411354,0.00062709,0.0008642009,0.002075054,0.0008367283,0.003197326,0.001054778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009098822,"about_ca_system_score_gemma":0.001240342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008352821,"about_ca_topic_score_gemma":0.00101961,"domain_scores_codex":[0.9995534,0.0001385449,0.00003906334,0.0000824712,0.0001375771,0.00004890583],"domain_scores_gemma":[0.9989549,0.0005061372,0.0001285788,0.00003608353,0.0002755586,0.00009864863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006649513,0.0009235655,0.0004335295,0.009539829,0.0001346811,0.000531929,0.0003034178,0.001197277,0.04469646,0.01352041,0.01987615,0.9081777],"study_design_scores_gemma":[0.0005869162,0.007005875,0.002711207,0.005687762,0.0003501423,0.002138091,0.0002955193,0.003419376,0.03888973,0.01291892,0.9258553,0.0001411017],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005117537,0.9792883,0.005943629,0.005395835,0.0008015811,0.00009932479,0.00007047738,0.00008549326,0.003197786],"genre_scores_gemma":[0.04590907,0.9375988,0.008858953,0.003796373,0.0009342119,0.0002661023,0.0001961031,0.00004486689,0.002395577],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003156863,"threshold_uncertainty_score":0.01388919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1061014793230243,"score_gpt":0.3764076686496348,"score_spread":0.2703061893266104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}