{"id":"W4213301589","doi":"10.1007/s12687-022-00582-3","title":"Considerations for developing regulations for direct-to-consumer genetic testing: a scoping review using the 3-I framework","year":2022,"lang":"en","type":"review","venue":"Journal of Community Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Clinical Evaluative Sciences; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Canada Excellence Research Chairs, Government of Canada","keywords":"Genetic testing; Legislation; Autonomy; Stakeholder; Health care; Public health; Business; Bioethics; Public relations; Political science; Medicine; Law; Nursing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.00166815,0.0003452731,0.001025939,0.000166131,0.00141756,0.00009479438,0.0008036238,0.0002247461,0.00001808075],"category_scores_gemma":[0.007435518,0.0002927655,0.0005724654,0.0004525273,0.000104589,0.00000466162,0.0003710272,0.0006786805,5.276216e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736944,"about_ca_system_score_gemma":0.004580364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003542239,"about_ca_topic_score_gemma":0.00003363388,"domain_scores_codex":[0.9968892,0.0009793342,0.001410429,0.0001888011,0.0002422192,0.0002900698],"domain_scores_gemma":[0.9928215,0.003713709,0.001414657,0.001035691,0.0009258313,0.00008862153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003622846,0.0002060142,0.00001834101,0.08769275,0.002138505,0.000002975243,0.0008728508,0.01284856,0.0002666529,0.0001566226,0.02349733,0.8722632],"study_design_scores_gemma":[0.0001752572,0.0002735947,0.000003395291,0.05640187,0.001970097,0.0003631932,0.00008981078,0.00004337116,0.00008464542,0.0008597128,0.9393478,0.0003872713],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007121129,0.9174298,0.07857429,0.0002939067,0.0005391639,0.00292586,0.0001315177,0.000005767287,0.00002850523],"genre_scores_gemma":[0.00002212159,0.6910655,0.3071949,0.0008253396,0.0003664675,0.000389421,0.00004616249,0.00007403672,0.0000160438],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9158505,"threshold_uncertainty_score":0.9999524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3104508436692055,"score_gpt":0.4601319660373183,"score_spread":0.1496811223681128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}