{"id":"W4213306332","doi":"10.1200/jco.2022.40.6_suppl.073","title":"Association between patient-reported outcomes (PROs) and changes in prostate-specific antigen (PSA) in patients (pts) with advanced prostate cancer treated with apalutamide (APA) in the SPARTAN and TITAN studies.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Janssen Research and Development","keywords":"Medicine; Prostate cancer; Oncology; Internal medicine; Proportional hazards model; Titan (rocket family); Placebo; Androgen deprivation therapy; Post-hoc analysis; Prostate-specific antigen; Prostate; Cancer; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003805103,0.0003804776,0.00082791,0.0003088721,0.0001807273,0.0005200303,0.0002854124,0.0005089141,0.0009516838],"category_scores_gemma":[0.002959689,0.0002382721,0.001515218,0.0005309304,0.0003440977,0.000447392,0.000474926,0.001152569,0.00007960314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002811229,"about_ca_system_score_gemma":0.0003397728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005211296,"about_ca_topic_score_gemma":0.00137228,"domain_scores_codex":[0.9985929,0.0009386141,0.0001155003,0.0001298645,0.0001330674,0.00008999054],"domain_scores_gemma":[0.9968101,0.001271996,0.001241474,0.0001063992,0.0001188091,0.0004511095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3722142,0.002294288,0.5790027,0.0009263299,0.00900762,0.000169419,0.0002169603,0.001414902,0.002919586,0.000106802,0.0005982778,0.03112892],"study_design_scores_gemma":[0.01499455,0.0600877,0.9187793,0.00006248826,0.003290574,0.0002034726,0.00009422677,0.001165353,0.0005106872,0.0001185862,0.0006585612,0.00003455287],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99709,0.002147086,0.00009384745,0.00006228582,0.00001359636,0.00006800197,0.0002682256,0.000002856605,0.0002540703],"genre_scores_gemma":[0.9991239,0.000322758,0.00008840449,0.00004969776,0.00001732702,0.00005969648,0.0002645295,6.835266e-7,0.00007314159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003805103,"threshold_uncertainty_score":0.02012354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1057076784255625,"score_gpt":0.438367632866634,"score_spread":0.3326599544410715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}