{"id":"W4213322353","doi":"10.1089/genbio.2021.0007","title":"TRAIL Therapy for Breast Cancer Treatment by Employing Lipopolymer mRNA Delivery","year":2022,"lang":"en","type":"article","venue":"GEN Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Apoptosis; Transfection; Breast cancer; Messenger RNA; Stromal cell; Polyethylenimine; Cancer research; Cytotoxicity; Cancer cell; Molecular biology; Cancer; Bone marrow; Tumor necrosis factor alpha; Biology; Chemistry; Cell culture; Medicine; In vitro; Immunology; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422311,0.0002516245,0.0001621458,0.000162268,0.0001052144,0.0002321922,0.00009655536,0.0002010766,0.000724408],"category_scores_gemma":[0.0001054166,0.00005955493,0.0001472535,0.0001396915,0.0001894428,0.0001715809,0.0001220408,0.0003331549,0.000329613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002472706,"about_ca_system_score_gemma":0.0002738932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002796313,"about_ca_topic_score_gemma":0.0004429471,"domain_scores_codex":[0.9999202,0.00001605363,0.000008011777,0.00001569318,0.00002606381,0.00001396189],"domain_scores_gemma":[0.9999676,0.000008178391,0.00001094223,0.000003335698,0.000006137278,0.000003813096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003647813,0.00001684175,0.00008687577,0.00007589387,0.000002488967,0.00005849074,0.00001438414,0.00011723,0.9930671,0.0001782096,0.00003428545,0.006311643],"study_design_scores_gemma":[0.00001108444,0.0002685386,0.0003099326,0.000006484386,0.00001322478,0.0001828095,0.000009923489,0.0005306819,0.994049,0.0000390409,0.004575916,0.000003302665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9291078,0.01721426,0.04783335,0.0004805895,0.000126795,0.0002374141,0.0002320098,0.0002970169,0.004470718],"genre_scores_gemma":[0.9645416,0.00837947,0.02228819,0.0001172084,0.00004208597,0.0001134632,0.0002359982,0.00003116285,0.004250776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000724408,"threshold_uncertainty_score":0.002423406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403094544206599,"score_gpt":0.2553165874426017,"score_spread":0.2412856420005357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}