{"id":"W4213327587","doi":"10.3390/antibiotics11030297","title":"Determination of the Relationships between the Chemical Structure and Antimicrobial Activity of a GAPDH-Related Fish Antimicrobial Peptide and Analogs Thereof","year":2022,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Antimicrobial; Glyceraldehyde 3-phosphate dehydrogenase; Antimicrobial peptides; Peptide; Chemistry; Biochemistry; Mode of action; Intracellular; Circular dichroism; Bacteria; Membrane; Enzyme; Dehydrogenase; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002491828,0.0001774516,0.0003392712,0.00006690958,0.0005928742,0.00001636954,0.0002637666,0.0002040823,0.00005751617],"category_scores_gemma":[0.00008973476,0.0001237919,0.0001052248,0.0002262221,0.001035409,0.00009444562,0.0004562639,0.0007323261,8.426318e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002096962,"about_ca_system_score_gemma":0.00005333578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001556015,"about_ca_topic_score_gemma":0.00003536475,"domain_scores_codex":[0.9987401,0.0004073196,0.0003355143,0.0002401513,0.00006007433,0.0002168569],"domain_scores_gemma":[0.9989186,0.0003314812,0.0004058431,0.0002745705,0.00005596765,0.0000135679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006186586,0.00006261447,0.05206224,0.00005351788,0.0001093491,6.492887e-7,0.0009518929,0.00001436921,0.9441295,0.0002417527,0.001487471,0.000824812],"study_design_scores_gemma":[0.0007764402,0.00008103957,0.1210242,0.00005568561,0.0002031668,0.0001243468,0.0003558281,0.00003691653,0.876556,0.0002302366,0.0003748014,0.000181253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979077,0.00006468168,0.00003267123,0.0007495115,0.0001985522,0.0002685138,0.0006558992,0.00001526305,0.000107208],"genre_scores_gemma":[0.9993976,0.00003800321,0.0001142906,0.00008586094,0.0000209677,2.354171e-7,0.00006384783,0.00001759665,0.0002615363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06896198,"threshold_uncertainty_score":0.5048087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333861210359202,"score_gpt":0.2179751401105671,"score_spread":0.204636528006975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}