{"id":"W4213328538","doi":"10.1093/jcag/gwab049.016","title":"A17 <i>TRP53</i> REGULATES ESLF-RENEWAL AND CELL DIFFERENTIATION IN <i>KRT15+ INTESTINAL STEM CELLS</i>","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Stem cell; Organoid; Biology; Cell biology; Intestinal epithelium; Wnt signaling pathway; LGR5; Paneth cell; Multipotent Stem Cell; Cellular differentiation; Stem cell marker; Adult stem cell; Intestinal mucosa; Cancer stem cell; Epithelium; Signal transduction; Small intestine; Genetics; Progenitor cell; Gene; Internal medicine; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332709,0.0002189599,0.0001786227,0.0002479228,0.0001037249,0.000285644,0.0001895294,0.0002235052,0.002085117],"category_scores_gemma":[0.00008418079,0.0001316897,0.0002637045,0.00009808828,0.0002737316,0.0001618267,0.0001588089,0.0005433203,0.000723072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001982091,"about_ca_system_score_gemma":0.0001365071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004935142,"about_ca_topic_score_gemma":0.0005804963,"domain_scores_codex":[0.9998498,0.00001839716,0.00002457881,0.00003579529,0.0000340968,0.00003733942],"domain_scores_gemma":[0.9998019,0.00002008586,0.00007471733,0.00002110548,0.00001582275,0.0000662672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006265844,0.00001338505,0.0002736438,0.00001242209,0.000002133008,0.00003603817,0.000007285589,0.0000203984,0.9991197,0.0000486266,0.00002555562,0.0003781818],"study_design_scores_gemma":[0.00001252846,0.000179255,0.008424448,0.000005950465,0.00001143836,0.0002651692,0.00004868121,0.0006676602,0.9885705,0.00002972904,0.001781433,0.000003230904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962246,0.0005129921,0.001525552,0.00006328687,0.00001545319,0.00001636418,0.0005645783,0.00007172977,0.001005382],"genre_scores_gemma":[0.9948241,0.0002908981,0.00102706,0.00005418759,0.00000495304,0.00002591829,0.000884975,0.0000444331,0.002843462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002085117,"threshold_uncertainty_score":0.006975412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007071868264785601,"score_gpt":0.1977935088082845,"score_spread":0.1907216405434989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}