{"id":"W4213330092","doi":"10.1111/cts.13210","title":"Pharmacokinetic equations versus Bayesian guided vancomycin monitoring: Pharmacokinetic model and model‐informed precision dosing trial simulations","year":2022,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; McGill University Health Centre; Université de Montréal","funders":"Pfizer","keywords":"Dosing; Bayesian probability; Prior probability; Vancomycin; Statistics; Computer science; Mathematics; Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005720467,0.0006197799,0.001014554,0.0003611739,0.0001439577,0.0007971628,0.0008946003,0.001186506,0.001379169],"category_scores_gemma":[0.02142476,0.0004025708,0.0007863194,0.0003908333,0.0003189809,0.000785444,0.0006292165,0.001331708,0.0001580748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009301929,"about_ca_system_score_gemma":0.001680823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00644148,"about_ca_topic_score_gemma":0.00348103,"domain_scores_codex":[0.9985739,0.001017755,0.00006704759,0.0001276913,0.0001386257,0.00007496367],"domain_scores_gemma":[0.9832736,0.01449334,0.0009301543,0.0003493712,0.0007875953,0.0001660191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001133066,0.0001529472,0.002954342,0.000105243,0.0001088881,0.00004538935,0.00003871084,0.9843826,0.0003414287,0.002679345,0.0004524574,0.007605503],"study_design_scores_gemma":[0.0001750373,0.0003700524,0.0005098722,0.0000258088,0.00005679986,0.0000127405,0.000008570451,0.9959204,0.0003536006,0.002290032,0.0002674297,0.000009579584],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8119626,0.001691868,0.1762628,0.00161671,0.0001012476,0.0004929333,0.001377914,0.0002795827,0.006214301],"genre_scores_gemma":[0.9726691,0.0003041787,0.024958,0.0002577811,0.00002245271,0.000419665,0.0005224703,0.00002564601,0.0008205724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00644148,"threshold_uncertainty_score":0.03025305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1809135824231365,"score_gpt":0.4663411039923834,"score_spread":0.2854275215692469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}