{"id":"W4213333599","doi":"10.1101/2022.02.12.480185","title":"The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Research, Development and Innovation Office; Horizon 2020 Framework Programme; Magyar Tudományos Akadémia; Innovációs és Technológiai Minisztérium; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Biotechnology and Biological Sciences Research Council; Cardiff University; Medical Research Council; Directorate for Biological Sciences; National Natural Science Foundation of China; Wellcome Trust","keywords":"Colistin; Antimicrobial peptides; Innate immune system; Virulence; Galleria mellonella; Antibiotic resistance; Biology; Antibiotics; Microbiology; Immune system; Antimicrobial; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458516,0.0002520769,0.0001822912,0.0001994924,0.000110377,0.0005239667,0.00011197,0.0004047062,0.001427883],"category_scores_gemma":[0.0001905001,0.00008326117,0.0001557297,0.0001840122,0.0003270042,0.0001924933,0.0004529914,0.0006982114,0.0003143175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002443239,"about_ca_system_score_gemma":0.0001139572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003247013,"about_ca_topic_score_gemma":0.0002651403,"domain_scores_codex":[0.9998374,0.0000397577,0.00001043323,0.00004033794,0.0000380875,0.00003387395],"domain_scores_gemma":[0.9998387,0.00002387382,0.0000632716,0.00003037907,0.00001225288,0.00003144596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005179,0.00002306857,0.003664593,0.00003029364,0.00001119067,0.0001640216,0.00002393866,0.0001691691,0.9933435,0.0003381267,0.00009688197,0.002034699],"study_design_scores_gemma":[0.00002733535,0.0004267503,0.07790927,0.000028853,0.00003439081,0.001620529,0.0002698281,0.003989608,0.9067205,0.000791911,0.00816717,0.00001377279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952397,0.0009433011,0.001557023,0.0002516805,0.00002487949,0.000005706713,0.0001195703,0.00003980117,0.001818222],"genre_scores_gemma":[0.9977883,0.000205226,0.0007572053,0.00006431437,0.000009227471,0.000003352187,0.00007242025,0.00001106751,0.001088844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001427883,"threshold_uncertainty_score":0.004776776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00784693128383798,"score_gpt":0.2022556548166309,"score_spread":0.1944087235327929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}