{"id":"W4213339523","doi":"10.1080/15476286.2022.2027150","title":"Innovative developments and emerging technologies in RNA therapeutics","year":2022,"lang":"en","type":"article","venue":"RNA Biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"RNA; Small interfering RNA; Computational biology; Biology; Oligonucleotide; Nucleic acid; RNA interference; Gene silencing; Ribozyme; microRNA; RNA silencing; RNA splicing; Drug development; Gene; Drug; Genetics; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001571409,0.001017534,0.0009586306,0.001443341,0.000583336,0.002148423,0.001060733,0.002118138,0.00481075],"category_scores_gemma":[0.001037162,0.0005259173,0.0006413458,0.001234635,0.001646714,0.003095278,0.001432782,0.003206104,0.004170401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009611273,"about_ca_system_score_gemma":0.001159067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002848977,"about_ca_topic_score_gemma":0.0003034657,"domain_scores_codex":[0.9986811,0.0002721125,0.00008693538,0.0002638604,0.0005880079,0.0001080145],"domain_scores_gemma":[0.9994475,0.0002709607,0.00006920949,0.00003703281,0.0001211386,0.0000540401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001453104,0.0002096836,0.0003879629,0.01059237,0.00006819543,0.001081144,0.0005864415,0.00195943,0.1473628,0.222258,0.01903689,0.5963119],"study_design_scores_gemma":[0.00001818265,0.0003441091,0.0002478411,0.0008745582,0.00003999525,0.001534419,0.0001203817,0.001507598,0.05081552,0.03166404,0.9127719,0.00006156387],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003841697,0.8927394,0.06014469,0.003962353,0.002597522,0.00009370319,0.0001275847,0.0003086946,0.03618437],"genre_scores_gemma":[0.03447073,0.8889359,0.05470125,0.003167332,0.003474111,0.0002757874,0.0002368274,0.0001071254,0.01463088],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00481075,"threshold_uncertainty_score":0.01609355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470922268279458,"score_gpt":0.2977276674237867,"score_spread":0.2830184447409921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}