{"id":"W4213339686","doi":"10.1093/jcag/gwab049.062","title":"A63 THE COLONIC PATHOGEN, <i>ENTAMOEBA HISTOLYTICA</i> ACTIVATES CASPASE-4 IN HUMAN MACROPHAGES THAT CLEAVES GASDERMIN D TO FACILITATE IL-1β SECRETION IN THE ABSENCE OF CELL DEATH","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Pyroptosis; Inflammasome; Caspase 1; Secretion; Cell biology; Entamoeba histolytica; Biology; HEK 293 cells; Caspase; Chemistry; Molecular biology; Programmed cell death; Cell culture; Inflammation; Microbiology; Biochemistry; Apoptosis; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002472861,0.0003085898,0.0002533428,0.0001599109,0.0001638641,0.0004859959,0.0001541829,0.0004880183,0.002825236],"category_scores_gemma":[0.00014647,0.0001783606,0.0003612123,0.0001540652,0.0002090891,0.0002875847,0.000173798,0.0005724631,0.00125572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254651,"about_ca_system_score_gemma":0.0001771004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004626027,"about_ca_topic_score_gemma":0.0004619329,"domain_scores_codex":[0.9996818,0.00005183392,0.00004483632,0.00008144936,0.00006506293,0.00007503031],"domain_scores_gemma":[0.9999259,0.0000114301,0.00002033438,0.00001425304,0.00001676654,0.00001130093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002465857,0.00003477858,0.0003819379,0.00007085242,0.000006226334,0.0001080637,0.00001658714,0.00002878503,0.9981956,0.00004801582,0.0001068476,0.0007558726],"study_design_scores_gemma":[0.00006665222,0.0006740449,0.01067942,0.00001790247,0.00002334938,0.001290988,0.0001232735,0.0008347164,0.9808125,0.0001030823,0.005366652,0.000007302279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872655,0.002653448,0.004384232,0.0003348346,0.0001270772,0.0001094368,0.001611276,0.0001277861,0.003386279],"genre_scores_gemma":[0.9877412,0.001118192,0.00334873,0.0002016604,0.00003859913,0.0001293891,0.002420231,0.00001702261,0.004984986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002825236,"threshold_uncertainty_score":0.00945133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01938442987410879,"score_gpt":0.2410857339743785,"score_spread":0.2217013041002697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}