{"id":"W4213347865","doi":"10.1200/jco.2022.40.6_suppl.tps580","title":"Adjuvant infigratinib as targeted therapy for patients with muscle-invasive urothelial carcinoma harboring susceptible<i> FGFR3 </i>genetic alterations: A randomized, double-blind, placebo-controlled, phase 3 trial (PROOF 302).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Cystectomy; Cisplatin; Tolerability; Chemotherapy; Urology; Internal medicine; Oncology; Bladder cancer; Placebo; Cancer; Gastroenterology; Adverse effect; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012321,0.00144995,0.002191433,0.0002986196,0.0002611089,0.0008047324,0.0007115937,0.00130214,0.005340951],"category_scores_gemma":[0.0008806525,0.0004678373,0.001624173,0.0003583565,0.0007096558,0.0009372646,0.0003310933,0.002089471,0.0007662267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006203476,"about_ca_system_score_gemma":0.001231054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006408683,"about_ca_topic_score_gemma":0.001935113,"domain_scores_codex":[0.9996521,0.0001683635,0.00002405015,0.00006911047,0.00002891917,0.00005735254],"domain_scores_gemma":[0.9996309,0.00006863478,0.0001069084,0.00002315264,0.00002963637,0.0001406917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9560304,0.005233692,0.0006553274,0.001724334,0.001058306,0.00005827766,0.00004762739,0.0004568526,0.007198997,0.0001533531,0.001932728,0.02545007],"study_design_scores_gemma":[0.9373273,0.05947325,0.001170302,0.000042424,0.0003626682,0.00006415283,0.00001351541,0.000322499,0.0004299222,0.0001108674,0.000671831,0.00001114752],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970121,0.01383176,0.001084077,0.001215022,0.0007313438,0.007296147,0.002203757,0.0003354559,0.003181406],"genre_scores_gemma":[0.9822723,0.004703995,0.001980412,0.001508317,0.0003023932,0.005005027,0.001961434,0.00003397602,0.002232267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005340951,"threshold_uncertainty_score":0.01786733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07437173397062297,"score_gpt":0.4142051565024548,"score_spread":0.3398334225318319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}