{"id":"W4213348369","doi":"10.1158/1078-0432.ccr-21-0344","title":"Targeting the Ubiquitin–Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; International Association for the Study of Lung Cancer; Weill Cornell Medical College; Canada Foundation for Innovation; National Center for Advancing Translational Sciences; Temerty Faculty of Medicine, University of Toronto; Ontario Institute for Cancer Research; Lung Cancer Research Foundation; National Cancer Institute; University of Toronto; Memorial Sloan-Kettering Cancer Center; American Society of Clinical Oncology; Cancer Research Society; National Institutes of Health; Conquer Cancer Foundation","keywords":"Lung cancer; Cancer; Gene; Therapeutic approach; Cell culture; Targeted therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.011659,0.0003465353,0.0007467282,0.0001738386,0.003484034,0.0002263301,0.001187024,0.000161435,0.0009863853],"category_scores_gemma":[0.0006048675,0.0002041188,0.0005137083,0.00113688,0.001042924,0.00009253652,0.001446785,0.003415729,0.000009863254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002169261,"about_ca_system_score_gemma":0.004055696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003836661,"about_ca_topic_score_gemma":0.0001466635,"domain_scores_codex":[0.9912789,0.002320895,0.001078701,0.001049703,0.002555136,0.00171669],"domain_scores_gemma":[0.994657,0.002407104,0.0002997274,0.0009730158,0.001319203,0.0003439687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0391953,0.004035157,0.1180452,0.02502589,0.01141729,0.0009747541,0.01706568,0.03012307,0.1066999,0.003323997,0.5432755,0.1008183],"study_design_scores_gemma":[0.03544613,0.01005873,0.007993625,0.003183864,0.003594388,0.0001866957,0.1003092,0.4580381,0.01586692,0.001073373,0.3616059,0.002643156],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7968825,0.1189045,0.001076012,0.05781335,0.003177279,0.01972089,0.001081433,0.0002454827,0.001098475],"genre_scores_gemma":[0.9783406,0.001829484,0.00008934122,0.001710855,0.004931343,0.00949768,0.00001779704,0.0001367133,0.003446137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.427915,"threshold_uncertainty_score":0.9999269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2792886795333899,"score_gpt":0.5313512002930797,"score_spread":0.2520625207596898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}