{"id":"W4213348369","doi":"10.1158/1078-0432.ccr-21-0344","title":"Targeting the Ubiquitin–Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; International Association for the Study of Lung Cancer; Weill Cornell Medical College; Canada Foundation for Innovation; National Center for Advancing Translational Sciences; Temerty Faculty of Medicine, University of Toronto; Ontario Institute for Cancer Research; Lung Cancer Research Foundation; National Cancer Institute; University of Toronto; Memorial Sloan-Kettering Cancer Center; American Society of Clinical Oncology; Cancer Research Society; National Institutes of Health; Conquer Cancer Foundation","keywords":"Lung cancer; Cancer; Gene; Therapeutic approach; Cell culture; Targeted therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205832,0.0004254626,0.0004410036,0.0002844412,0.0001844906,0.000506451,0.0003270856,0.0002848548,0.001736148],"category_scores_gemma":[0.0001046075,0.0001311308,0.0004610072,0.0002638071,0.0002574481,0.0002583481,0.0001633661,0.0007986185,0.0005090869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002927869,"about_ca_system_score_gemma":0.0003076081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002198334,"about_ca_topic_score_gemma":0.0007364664,"domain_scores_codex":[0.9999138,0.00001422701,0.000009101082,0.00001746699,0.00002417242,0.00002119701],"domain_scores_gemma":[0.9999301,0.0000129901,0.00002226541,0.000006733887,0.000009246963,0.00001854602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001161481,0.0005897079,0.001484471,0.0005083755,0.00006903643,0.0002330753,0.00003432219,0.000817439,0.958616,0.0002105168,0.0006189761,0.03565666],"study_design_scores_gemma":[0.0003988579,0.01343171,0.01281212,0.00006496587,0.0002664365,0.001671579,0.0001001073,0.002770482,0.9546171,0.0002221825,0.01361287,0.00003160398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498312,0.04100181,0.004037921,0.0005745332,0.0001458931,0.0001881788,0.0006264698,0.0003089789,0.00328514],"genre_scores_gemma":[0.9868019,0.009066644,0.001809022,0.0001570719,0.00004132562,0.0000867772,0.0006574592,0.00001136327,0.001368411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001736148,"threshold_uncertainty_score":0.005807936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2792886795333899,"score_gpt":0.5313512002930797,"score_spread":0.2520625207596898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}