{"id":"W4213351992","doi":"10.1101/2022.02.11.22270852","title":"Polygenic coronary artery disease association with brain atrophy in the cognitively impaired","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Eisai; Servier; Engineering and Physical Sciences Research Council; Institut National de la Santé et de la Recherche Médicale; University of Southern California; University College London; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Alzheimer's Society; University College London Hospitals NHS Foundation Trust; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Brain size; Atrophy; Dementia; Context (archaeology); Medicine; Hyperintensity; Internal medicine; Cardiology; Disease; Alzheimer's Disease Neuroimaging Initiative; Magnetic resonance imaging; Biology; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009817806,0.0004025153,0.0003546917,0.001027199,0.0003829501,0.0005791059,0.0003417826,0.0004460168,0.002779336],"category_scores_gemma":[0.002130734,0.000199035,0.000590867,0.0009114874,0.0004233585,0.0002187867,0.0005162326,0.0004323126,0.0002212936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001451323,"about_ca_system_score_gemma":0.0001889493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009027089,"about_ca_topic_score_gemma":0.008168938,"domain_scores_codex":[0.9994789,0.0002084068,0.00003746869,0.0001600639,0.00005205273,0.00006322622],"domain_scores_gemma":[0.9987758,0.0004481836,0.0003213025,0.0001925121,0.00009009419,0.0001720228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005098224,0.00005951195,0.9939611,0.00001346425,0.0004241941,0.0002688085,0.0001083638,0.0003467524,0.0019715,0.0000992968,0.0001219758,0.002115296],"study_design_scores_gemma":[0.000004539757,0.00004026394,0.9990373,0.000002064095,0.00005660521,0.0001345771,0.00002596013,0.0005318527,0.00005131775,0.0000787289,0.00003437562,0.000002444404],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992152,0.00008920999,0.0002393547,0.00002509056,0.00000256598,0.00000296063,0.0001774831,0.000006196754,0.0002419696],"genre_scores_gemma":[0.9996461,0.00002213149,0.00009091477,0.000006597367,0.000004164472,0.000001764119,0.0001448756,0.000001858372,0.00008161735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009027089,"threshold_uncertainty_score":0.0179491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01345816973395988,"score_gpt":0.25333885383538,"score_spread":0.2398806841014201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}