{"id":"W4213369447","doi":"10.3389/fneur.2021.788168","title":"Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Review of Clinical Manifestations as Foundations for Therapeutic Development","year":2022,"lang":"en","type":"review","venue":"Frontiers in Neurology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Medicine; Neuropathology; Clinical trial; Leukoencephalopathy; Disease; Intensive care medicine; Leukodystrophy; Neuroscience; Pathology; Bioinformatics; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006456089,0.0004172787,0.001479371,0.0003493953,0.0002614428,0.00002708812,0.000449034,0.0001644405,0.0002014464],"category_scores_gemma":[0.0008987508,0.0003688889,0.0002194867,0.0005948727,0.0002487977,0.0001203148,0.0001260558,0.0005416177,0.00000932579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004000345,"about_ca_system_score_gemma":0.000947768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001397956,"about_ca_topic_score_gemma":0.00001155018,"domain_scores_codex":[0.9948899,0.001580592,0.001777876,0.001012526,0.0003964272,0.0003426425],"domain_scores_gemma":[0.997184,0.001166784,0.001029321,0.0004265447,0.00007915919,0.0001141504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004424749,0.000590555,0.0002166995,0.0341902,0.0001083795,0.0002960186,0.0001752991,0.00001551652,0.00003939334,0.007803491,0.007095677,0.9490263],"study_design_scores_gemma":[0.0008033765,0.0008515489,0.0000229837,0.001651652,0.0002229206,0.0005348862,0.00001285354,0.0001431207,0.00007174639,0.0002916594,0.995073,0.0003202528],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007288718,0.9760446,0.01219992,0.0009991742,0.003296737,0.00600698,0.0002259455,0.0001196299,0.0003781684],"genre_scores_gemma":[0.00002655288,0.9879034,0.004485826,0.005717609,0.00004541429,0.001353067,0.0001728445,0.00007023073,0.0002250514],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9879773,"threshold_uncertainty_score":0.9998763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1165412883663703,"score_gpt":0.3888454599452526,"score_spread":0.2723041715788823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}