{"id":"W4213370194","doi":"10.1093/eurjpc/zwac025","title":"Rationale and design of two trials assessing the efficacy, safety, and tolerability of inclisiran in adolescents with homozygous and heterozygous familial hypercholesterolaemia","year":2022,"lang":"en","type":"article","venue":"European Journal of Preventive Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Novartis Institutes for BioMedical Research; Novartis Pharma","keywords":"Medicine; Tolerability; Familial hypercholesterolemia; Clinical endpoint; Statin; Surrogate endpoint; Adverse effect; Placebo; Internal medicine; Pediatrics; Disease; Compound heterozygosity; Clinical trial; Cholesterol; Mutation; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08522096,0.0050636,0.00694636,0.001791373,0.002012424,0.00316546,0.003488944,0.008349755,0.02011001],"category_scores_gemma":[0.08110352,0.002344011,0.005548083,0.002018292,0.003620139,0.003133371,0.001606522,0.006811324,0.00494137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002805969,"about_ca_system_score_gemma":0.008334364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008824617,"about_ca_topic_score_gemma":0.001289449,"domain_scores_codex":[0.9270804,0.05611835,0.00601095,0.004531556,0.003936876,0.002321848],"domain_scores_gemma":[0.9633302,0.01612997,0.00676074,0.004092174,0.00542753,0.004259304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.847155,0.00835946,0.007799088,0.03028267,0.007047035,0.0008284959,0.0007284057,0.001677187,0.00350858,0.01270214,0.01215679,0.06775521],"study_design_scores_gemma":[0.8530889,0.05834405,0.006222778,0.004997938,0.007276327,0.0002783168,0.0002215121,0.001997772,0.001567906,0.007340421,0.05849459,0.0001694128],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01163712,0.006419432,0.006694371,0.002484733,0.002801778,0.9632475,0.00172768,0.0001422557,0.004845004],"genre_scores_gemma":[0.03204722,0.001193398,0.01168245,0.002724261,0.0005285883,0.9501004,0.0004733396,0.00001546848,0.001234782],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.08522096,"threshold_uncertainty_score":0.4506969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04692933481646987,"score_gpt":0.3152609561642302,"score_spread":0.2683316213477603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}