{"id":"W4213389062","doi":"10.1093/jcag/gwab049.128","title":"A129 CYP2C19 PHARMACOGENETIC TESTING IN PAEDIATRIC PATIENTS WITH EOSINOPHILIC ESOPHAGITIS INFLUENCES DOSING OF PROTON-PUMP-INHIBITORS AND RESPONSE TO THERAPY","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Eosinophilic Esophagitis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"CYP2C19; Eosinophilic esophagitis; Rabeprazole; Medicine; Proton-pump inhibitor; Pharmacogenetics; Internal medicine; Dosing; Lansoprazole; Gastroenterology; Omeprazole; Nerd; GERD; Pharmacology; Disease; Genotype; Reflux; Metabolism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009119379,0.0002652548,0.0006473927,0.0004367312,0.0002722696,0.0005570339,0.0003107423,0.0004311664,0.002288728],"category_scores_gemma":[0.004221771,0.0002070823,0.0008674948,0.000819977,0.0003061155,0.0004377125,0.0003512788,0.0007047511,0.0002506466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004536184,"about_ca_system_score_gemma":0.0005503212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002725825,"about_ca_topic_score_gemma":0.001861334,"domain_scores_codex":[0.9989177,0.0004481934,0.00009600451,0.0002333347,0.0001654641,0.0001393403],"domain_scores_gemma":[0.9973305,0.000831373,0.001297335,0.0001358341,0.0001621597,0.0002427794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005562029,0.00003709329,0.9967559,0.00002886394,0.00006310811,0.000234862,0.00007100865,0.00007915153,0.000355519,0.00002528453,0.0001237649,0.001669195],"study_design_scores_gemma":[0.00002729596,0.0003920711,0.998162,0.00001219544,0.00005487966,0.0006606812,0.00007253842,0.0001499143,0.0001589975,0.0000229209,0.0002830425,0.000003375723],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976125,0.0006364047,0.0002290792,0.00007967939,0.000007779195,0.00003216132,0.000743287,0.000006921124,0.0006523306],"genre_scores_gemma":[0.9989622,0.0001511907,0.0002259418,0.0000334655,0.000008608613,0.00003018309,0.0004480191,0.000004475781,0.000136008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002725825,"threshold_uncertainty_score":0.007656574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00869332587271874,"score_gpt":0.2324485018614307,"score_spread":0.2237551759887119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}