{"id":"W4213414836","doi":"10.3390/ijms23052455","title":"A New Family of Transcriptional Regulators Activating Biosynthetic Gene Clusters for Secondary Metabolites","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agentúra na Podporu Výskumu a Vývoja; Slovenská Akadémia Vied; McMaster University","keywords":"Operon; Gene; Gene cluster; Biology; Genetics; Regulator gene; Regulation of gene expression; Transcriptional regulation; Activator (genetics); Gene family; Transcription (linguistics); Coactivator; Reporter gene; Promoter; Mutant; Transcription factor; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329814,0.0007926996,0.0007189791,0.0004869442,0.000297584,0.0005130918,0.000281098,0.0002992253,0.001800027],"category_scores_gemma":[0.0001696594,0.000194753,0.0005215955,0.000383668,0.0002624564,0.0002189373,0.0004383643,0.0006701116,0.0008682171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005102769,"about_ca_system_score_gemma":0.0002900652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006150989,"about_ca_topic_score_gemma":0.00078317,"domain_scores_codex":[0.9996926,0.0000203506,0.00001342792,0.0001268073,0.00008715523,0.00005976282],"domain_scores_gemma":[0.9997637,0.00004621023,0.00006423853,0.00002324745,0.00003585783,0.00006675586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001764553,0.00002456836,0.001851236,0.0001169854,0.00000773037,0.0002857623,0.00004595181,0.0001566722,0.9877576,0.0002997,0.0002442754,0.009032926],"study_design_scores_gemma":[0.00009096535,0.0005019817,0.08109792,0.00007508683,0.0001159802,0.003658271,0.0002044512,0.005808276,0.8327954,0.0009594447,0.07462218,0.00007000264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9140593,0.01786639,0.04766121,0.0005314559,0.0002341471,0.0002040753,0.006298683,0.00303715,0.01010768],"genre_scores_gemma":[0.9570878,0.003856183,0.01742276,0.0005062973,0.0002194605,0.0002403804,0.009522622,0.0003103408,0.01083414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001800027,"threshold_uncertainty_score":0.006021678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01823282608567698,"score_gpt":0.2709232068101958,"score_spread":0.2526903807245188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}