{"id":"W4213423229","doi":"10.1186/s12933-022-01458-z","title":"MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes","year":2022,"lang":"en","type":"article","venue":"Cardiovascular Diabetology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; St. Michael's Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Canadian Vascular Network","keywords":"Endothelial dysfunction; Medicine; Internal medicine; Downregulation and upregulation; Diastole; Cardiology; Diabetes mellitus; Type 2 diabetes; Oxidative stress; Heart failure; Ejection fraction; Biomarker; Endocrinology; Biology; Blood pressure; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001229828,0.0002430223,0.0006828033,0.0001443469,0.00009439627,0.000009176101,0.0001632027,0.0002554463,0.00003029891],"category_scores_gemma":[0.00009165374,0.0002753688,0.0005164673,0.0001626052,0.0003403609,0.00002112393,0.0003801229,0.0002019086,6.054652e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002268875,"about_ca_system_score_gemma":0.00006971171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001708693,"about_ca_topic_score_gemma":0.000002150879,"domain_scores_codex":[0.9971371,0.0008697576,0.0006673125,0.0007497547,0.0002688652,0.000307183],"domain_scores_gemma":[0.9988369,0.00005909737,0.0002627259,0.0006672362,0.00008481053,0.00008924241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001071835,0.0002049165,0.1479316,0.0002521712,0.0009447304,0.000007516901,0.0001394716,0.000752295,0.8381715,0.00001136791,0.00002101938,0.01145627],"study_design_scores_gemma":[0.00440091,0.0005853279,0.1989819,0.00003232734,0.0008120005,0.00005468996,0.0001946577,0.005727905,0.787819,0.0004793732,0.0004711236,0.0004407044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640657,0.03055369,0.004463941,0.0000219196,0.0001860418,0.0005858568,0.00006469821,0.00001172558,0.00004636628],"genre_scores_gemma":[0.9981422,0.0003700182,0.000994764,0.00004829351,0.00005165105,0.0001137851,0.0002291949,0.00004055569,0.000009515205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05105038,"threshold_uncertainty_score":0.9999698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588531263281258,"score_gpt":0.2343030717691567,"score_spread":0.2184177591363441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}