{"id":"W4213423229","doi":"10.1186/s12933-022-01458-z","title":"MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes","year":2022,"lang":"en","type":"article","venue":"Cardiovascular Diabetology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; St. Michael's Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Canadian Vascular Network","keywords":"Endothelial dysfunction; Medicine; Internal medicine; Downregulation and upregulation; Diastole; Cardiology; Diabetes mellitus; Type 2 diabetes; Oxidative stress; Heart failure; Ejection fraction; Biomarker; Endocrinology; Biology; Blood pressure; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004609946,0.0004155538,0.0004815278,0.0005308376,0.000196646,0.000492284,0.0001446636,0.0003806075,0.001270921],"category_scores_gemma":[0.0003912581,0.000200669,0.0003549395,0.0002151869,0.0002946319,0.0002484017,0.0003295153,0.0008653649,0.0004052254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002774759,"about_ca_system_score_gemma":0.0001810514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001781532,"about_ca_topic_score_gemma":0.0001976764,"domain_scores_codex":[0.9996618,0.00005731854,0.0000305917,0.00009536446,0.0001009214,0.00005394869],"domain_scores_gemma":[0.9995301,0.00005025616,0.0001810947,0.00003584275,0.00007725492,0.000125471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002004662,0.0001211601,0.003901499,0.0001213246,0.00004287274,0.0001259046,0.00004658653,0.00005547208,0.9901652,0.0001072218,0.0001242855,0.003183881],"study_design_scores_gemma":[0.000122378,0.002266967,0.1018995,0.00006249343,0.0002121902,0.001497375,0.0001706733,0.001973588,0.8876477,0.0003968378,0.003719198,0.00003103199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885843,0.003466356,0.005543117,0.0001547113,0.00009550048,0.00004583212,0.0005529735,0.0001498404,0.001407441],"genre_scores_gemma":[0.9930855,0.001130547,0.003523334,0.0001562089,0.00003384753,0.00008575835,0.0005040872,0.0000400443,0.00144065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270921,"threshold_uncertainty_score":0.004251659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588531263281258,"score_gpt":0.2343030717691567,"score_spread":0.2184177591363441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}