{"id":"W4213427186","doi":"10.1200/jco.21.00714","title":"Selumetinib Plus Adjuvant Radioactive Iodine in Patients With High-Risk Differentiated Thyroid Cancer: A Phase III, Randomized, Placebo-Controlled Trial (ASTRA)","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; AstraZeneca","keywords":"Medicine; Radioactive iodine; Selumetinib; Placebo; Thyroid cancer; Adjuvant; Randomized controlled trial; Oncology; Internal medicine; Cancer; Thyroid; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001851993,0.001425222,0.002719794,0.0004439769,0.0004417855,0.001006501,0.0006851099,0.001483088,0.0047358],"category_scores_gemma":[0.001428665,0.0005620075,0.002204845,0.0004761231,0.001169756,0.0008218321,0.0003212071,0.002113255,0.0007840407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006558895,"about_ca_system_score_gemma":0.001397609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007337047,"about_ca_topic_score_gemma":0.002439965,"domain_scores_codex":[0.9993887,0.0003179177,0.00005431788,0.0001050888,0.00005454421,0.00007943321],"domain_scores_gemma":[0.9994485,0.0001314101,0.0001530433,0.00004008369,0.00005337807,0.0001734898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9734786,0.004912452,0.0007737756,0.001041816,0.001421395,0.00003688921,0.00005212965,0.0002969736,0.003295098,0.0001228191,0.001079751,0.01348843],"study_design_scores_gemma":[0.9505973,0.04664557,0.0009807176,0.0000257688,0.0005687516,0.00002587851,0.00001479731,0.0001984185,0.0002707325,0.00008718479,0.0005757216,0.000009216751],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737833,0.01180164,0.0007535027,0.0011449,0.000826597,0.006633187,0.001955664,0.0001993395,0.002901823],"genre_scores_gemma":[0.9772072,0.005864811,0.001967941,0.001682935,0.0007591732,0.008269269,0.001381714,0.00002240691,0.002844505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0047358,"threshold_uncertainty_score":0.0158428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03123279664049053,"score_gpt":0.3837636869297161,"score_spread":0.3525308902892256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}