{"id":"W4213428886","doi":"10.3390/curroncol29030117","title":"Urothelial Bladder Carcinomas with High Tumor Mutation Burden Have a Better Prognosis and Targetable Molecular Defects beyond Immunotherapies","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"Medicine; Immunotherapy; Bladder cancer; Oncology; Immune checkpoint; Cancer research; Metastatic Urothelial Carcinoma; Cancer; Mutation; Microsatellite instability; Internal medicine; Gene; Urothelial carcinoma; Biology; Allele; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003976134,0.0003017408,0.0006535206,0.001298822,0.0004391106,0.0009903224,0.000237772,0.0003920096,0.003620601],"category_scores_gemma":[0.001010975,0.0001525816,0.0004762591,0.001868595,0.0002430235,0.0004435989,0.0006473844,0.000394967,0.000509617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004759814,"about_ca_system_score_gemma":0.0003966198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009317824,"about_ca_topic_score_gemma":0.001012748,"domain_scores_codex":[0.9996899,0.00004019606,0.00003619003,0.00008627823,0.00008954993,0.00005782577],"domain_scores_gemma":[0.9989107,0.0001382329,0.0006096765,0.0001048126,0.0001055919,0.0001309321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009039499,0.0001389168,0.8953537,0.0006637297,0.000497172,0.0007834805,0.0001531633,0.001093476,0.06173525,0.0005711655,0.001003266,0.03710274],"study_design_scores_gemma":[0.00001342581,0.0001562907,0.9837729,0.00005223233,0.0002273695,0.002906352,0.0001219686,0.0010772,0.007710557,0.0006628423,0.00328658,0.00001228179],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893902,0.004323483,0.001899218,0.0001491621,0.00001864746,0.00002761501,0.002931372,0.0000993683,0.001160996],"genre_scores_gemma":[0.9956905,0.0007929252,0.0009252566,0.0000425296,0.00001097203,0.00002220491,0.00211139,0.00001793148,0.0003864028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003620601,"threshold_uncertainty_score":0.01211208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02352900929782259,"score_gpt":0.3012844733004553,"score_spread":0.2777554640026327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}