{"id":"W4213428886","doi":"10.3390/curroncol29030117","title":"Urothelial Bladder Carcinomas with High Tumor Mutation Burden Have a Better Prognosis and Targetable Molecular Defects beyond Immunotherapies","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"Medicine; Immunotherapy; Bladder cancer; Oncology; Immune checkpoint; Cancer research; Metastatic Urothelial Carcinoma; Cancer; Mutation; Microsatellite instability; Internal medicine; Gene; Urothelial carcinoma; Biology; Allele; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059987,0.000231846,0.0003950538,0.0001358313,0.0002126392,0.00002125562,0.00008037045,0.00004760644,0.0005998081],"category_scores_gemma":[0.00001027447,0.0001905102,0.00007051921,0.0001385093,0.0001373905,0.00006528961,0.00008391061,0.0003161263,0.000009512631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002791354,"about_ca_system_score_gemma":0.0003385865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002766183,"about_ca_topic_score_gemma":0.00002791828,"domain_scores_codex":[0.9985767,0.0001521495,0.00021287,0.0004130507,0.0003028927,0.0003423369],"domain_scores_gemma":[0.9994563,0.00004358894,0.0001116797,0.0001936477,0.00008505307,0.0001097156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009008984,0.00486871,0.7326377,0.0006956681,0.003252202,0.004034456,0.02062257,0.0002609355,0.05219894,0.0009690572,0.006147534,0.1653032],"study_design_scores_gemma":[0.07348902,0.04473078,0.2495599,0.0002312135,0.005532806,0.004537572,0.006222315,0.0007707708,0.06631585,0.00431439,0.5421317,0.002163674],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888137,0.00671541,0.0001156999,0.001830092,0.0003996513,0.001214189,0.00006934788,0.00005816419,0.0007837197],"genre_scores_gemma":[0.9966393,0.00004770601,0.000652176,0.0009342355,0.0002275728,0.001141793,0.0001195272,0.00005141034,0.000186279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5359842,"threshold_uncertainty_score":0.7768782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02352900929782259,"score_gpt":0.3012844733004553,"score_spread":0.2777554640026327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}